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GM-CSF

요약

Name:Macrophage colony stimulating factor 2
Target Synonym:GM-CSF,Molgramostin,CSF2,Colony Stimulating Factor 2,Sargramostim,GMCSF,CSF,Granulocyte Macrophage-Colony Stimulating Factor,Granulocyte-Macrophage Colony Stimulating Factor,Colony-Stimulating Factor,Granulocyte-Macrophage Colony-Stimulating Factor,Colony Stimulating Factor 2 (Granulocyte-Macrophage),Molgramostim
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:9
Lastest Research Phase:NDA/BLA

제품 리스트 비교 또는 구매

일부의 생물활성 데이터

GMF-H4214-Cell-based assay
 GM-CSF CELL

The bio-activity was determined by dose-dependent stimulation of the proliferation of TF-1 cells. The ED50 < 0.1 ng/mL, corresponding to a specific activity of > 1x107 Unit/mg.

GMF-H8214-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Biotinylated Human GM-CSF, epitope tag free, primary amine labeling (Cat. No. GMF-H8214) on SA Biosensor, can bind Human GM-CSF R alpha, His Tag (SPR verified) (Cat. No. GRA-H52H7) with an affinity constant of 23.1 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

GMF-H4214-BLI
 GM-CSF BLI

Loaded Human GM-CSF R alpha, Fc Tag (Cat. No. GRA-H5255) on Protein A Biosensor, can bind Human GM-CSF, premium grade (Cat. No. GMF-H4214) with an affinity constant of 9.21 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Synonym Name

GM-CSF,CSF2,MGC131935

Background

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is also known as Colony stimulating factor 2 (granulocyte-macrophage), is a cytokine initially characterized by its ability to induce colonies of granulocytes and macrophages from myeloid progenitor cells, and is secreted by macrophages, T cells, mast cells, endothelial cells and fibroblasts. GM-CSF is a cytokine that functions as a white blood cell growth factor. GM-CSF stimulates stem cells to produce granulocytes (neutrophils, eosinophils, and basophils) and monocytes. Monocytes exitthe circulation and migrate into tissue, whereupon they mature into macrophages and dendritic cells. Thus, it is part of the immune/inflammatory cascade, by which activation of a small number of macrophages can rapidly lead to an increase in their numbers, a process crucial for fighting infection. The active form of the protein is found extracellularly as a homodimer. Human GM-CSF glycosylated in its mature form. As a part of the immune/inflammatory cascade, GM-CSF promotes Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity, and thus worthy of consideration for therapeutic target. GM-CSF has also recently been evaluated in clinical trials for its potential as a vaccine adjuvant in HIV-infected patients. The preliminary results have been promising. GM-CSF is also used as a medication to stimulate the production of white blood cells following chemotherapy.

Clinical and Translational Updates

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
PBI-1402 PBI-1402 Phase 2 Clinical Prometic Life Sciences Anemia Details
PD-360324 PD-360324; PD-0360324 Pfizer Pharmaceuticals Ltd (China) Details
Plonmarlimab TJ-003234RAR101; TJM-2; TJ-003234 Phase 2 Clinical I-Mab Biopharma Co Ltd Coronavirus Disease 2019 (COVID-19); Arthritis, Rheumatoid Details
SAR-441000 SAR441000; SAR-441000; BNT-131 Biontech Se, Sanofi Details
Namilumab MT-203; AMG-203; IZN-101 Takeda Pharmaceutical Co Ltd, Amgen Inc Details
Pexastimogene devacirepvec TG-6006; JX-594 Phase 2 Clinical Sillajen, Regeneron Pharmaceuticals Inc, National Cancer Institute, Samsung Medical Center & Samsung Electronics Devices Llc Sarcoma, Ewing; Neoplasm Metastasis; Melanoma; Carcinoma, Hepatocellular; Lymphoma; Lung Neoplasms; Colorectal Neoplasms; Sarcoma; Breast Neoplasms; Liver Neoplasms; Neuroblastoma; Neoplasms; Wilms Tumor; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Solid tumours; Rhabdomyosarcoma Details
Vusolimogene oderparepvec RP-1 Phase 2 Clinical Replimune Skin Melanoma; Carcinoma, Basal Cell; Carcinoma, Merkel Cell; Skin Neoplasms; Neoplasms; Microsatellite Instability; Carcinoma, Squamous Cell; Melanoma; Carcinoma, Non-Small-Cell Lung Details
Gimsilumab MORAb-022; KIN-1901 Phase 2 Clinical Morphotek Arthritis, Rheumatoid; Coronavirus Disease 2019 (COVID-19); Rheumatic Diseases; Inflammation Details
BT-001 BT-001 Phase 2 Clinical Transgene Solid tumours; Carcinoma, Merkel Cell; Neoplasms; Triple Negative Breast Neoplasms; Sarcoma; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Melanoma Details
Otilimab MOR-04357; GSK-3196165; GSK-165; MOR-103 Phase 3 Clinical University Of Melbourne Arthritis, Rheumatoid; Spondylarthritis; Multiple Sclerosis; Severe Acute Respiratory Syndrome; Osteoarthritis Details
Bi-shRNAfurin and GMCSF augmented autologous tumor cell immunotherapy (Gradalis/Mary Crowley) IND-14205 Phase 3 Clinical Gradalis Ovarian Neoplasms; Liver Neoplasms; Colonic Neoplasms; Breast Neoplasms; Sarcoma, Ewing; Peritoneal Neoplasms; Genital Neoplasms, Female; Uterine Neoplasms; Fallopian Tube Neoplasms; Endometrial Neoplasms; Lung Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung; Melanoma Details

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