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EphB4

요약

Name:Ephrin type-B receptor 4
Target Synonym:Ephrin type-B receptor 4,MYK1,EPHB4,HTK,EPH Receptor B4,Tyrosine-Protein Kinase TYRO11,TYRO11,Tyrosine-Protein Kinase Receptor HTK,Soluble EPHB4 Variant 2,Soluble EPHB4 Variant 3,Ephrin Receptor EphB4,EC 2.7.10.1,HFASD,LMPHM7,CMAVM2,EC 2.7.10,EC:2.7.10.1,Soluble EPHB4 Variant 1,Receptor, EphB4,Hepatoma transmembrane kinase
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Pending

제품 리스트 비교 또는 구매

Synonym Name

EphB4,HTK,MYK1,TYRO11

Background

Ephrin type-B receptor 4(EPHB4) is also known as HTK, MYK1 and TYRO11,is a member of Eph family. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by EPHB4 binds to Ephrin-B2 and plays an essential role in vascular development. EPHB4 and its ligand ephrin-B2 are specifically expressed on venous and arterial endothelial cells, respectively, and play an essential role in vascular development via bidirectional signals. The forward EPHB4 signaling inhibits cell adhesion, chemotaxis, angiogenesis and tumor growth. Incontrast, the reverse Ephrin-B2 signaling exerts the opposite effect. It has been reported that aberrant expression of EPHB4 is associated with prostate cancer and highly malignant breast cancers, accordingly, EPHB4 has potential application as a therapeutic candidate.

Clinical and Translational Updates

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
JI-101 JI-101; CGI-1842 Gilead Sciences Inc, Jubilant Innovation Details
sEphB4-HSA Vas-01; sEphB4-HSA Vasgene Details
TG-100801 TG-100801 Sanofi Details

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