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EpCAM

요약

Name:Epithelial cell adhesion molecule
Target Synonym:Epithelial Cell Adhesion Molecule,Tumor-Associated Calcium Signal Transducer 1,Major Gastrointestinal Tumor-Associated Protein GA733-2,Cell Surface Glycoprotein Trop-1,Epithelial Glycoprotein 314,TROP1,KSA,Membrane Component, Chromosome 4, Surface Marker (35kD Glycoprotein),Antigen Identified By Monoclonal Antibody AUA1,Human Epithelial Glycoprotein-2,Epithelial Cell Surface Antigen,CD326 Antigen,HEGP314,HNPCC8,Ep-CAM,DIAR5,EGP-2,EGP40,KS1/4,MK-1,M1S2,ESA,Ly74,TACST-1,CO-17A,17-1A,EGP34,HEA125,M
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:6
Lastest Research Phase:Phase 3 Clinical

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일부의 생물활성 데이터

EPM-H82F9-MALS-HPLC
Biotinylated Human EpCAM, Fc,Avitag (Cat. No. ) MALS images

The purity of Biotinylated Human EpCAM, Fc,Avitag (Cat. No. EPM-H82F9) is more than 90% and the molecular weight of this protein is around 115-130 kDa verified by SEC-MALS.

  • Background
    EpCAM is also known as CO171A, EGP, EGP40,GA7332, KSA, M4S, MIC18, MK1, TROP1, hEGP2, and is a pan-epithelial differentiation antigen that is expressed on almost all carcinomas as 17-1A(mAb) antigen. Its constitutional function is being elucidated. It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signaling and polarity. The epithelial cell adhesion molecule (Ep-CAM) is known to express in most epithelial malignancies and was reported as a tumor marker or a candidate of molecular targeting therapy. Ep-CAM cross signaling with N-cadherin involves Pi3K, resulting in the abrogation of the cadherin adhesion complexes in epithelial cells was reported. And Epithelial cell adhesion molecule (Ep-CAM) recently received increased attention as a prognostic factor in breast cancer.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

    EPM-H82E8-MALS-HPLC
    Biotinylated Human EpCAM, Avitag,His Tag (Cat. No. ) MALS images

    The purity of Biotinylated Human EpCAM, Avitag,His Tag (Cat. No. EPM-H82E8) is more than 90% and the molecular weight of this protein is around 30-40 kDa verified by SEC-MALS.

사용자 리뷰

Synonym Name

EPCAM,TACSTD1,TROP1,CD326,DIAR5,EGP2,EGP314,EGP40,ESA,GA733-2,HNPCC8,HNPCC-8,KS1,4,KSA,M4S1,MIC18,MK1

Background

EpCAM is also known as CO171A, EGP, EGP40,GA7332, KSA, M4S, MIC18, MK1, TROP1, hEGP2, and is a pan-epithelial differentiation antigen that is expressed on almost all carcinomas as 17-1A(mAb) antigen. Its constitutional function is being elucidated. It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signaling and polarity. The epithelial cell adhesion molecule (Ep-CAM) is known to express in most epithelial malignancies and was reported as a tumor marker or a candidate of molecular targeting therapy.Ep-CAM cross signaling with N-cadherin involves Pi3K, resulting in the abrogation of the cadherin adhesion complexes in epithelial cells was reported. And Epithelial cell adhesion molecule (Ep-CAM) recently received increased attention as a prognostic factor in breast cancer.

Clinical and Translational Updates

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
Anti-EPCAM CAR-T cell therapy (Sinobioway) Phase 2 Clinical Beijing Sinobioway Bioengineering Group Co Ltd Liver Neoplasms; Stomach Neoplasms Details
A-337 A-337 Phase 1 Clinical Evive Biotech Ltd Neoplasms Details
Tefibazumab INH-H2002 Bristol-Myers Squibb Company Details
Catumaxomab LP000 Phase 3 Clinical Trion Research, Neovii Biotech Stomach Neoplasms; Ascites; Urinary Bladder Neoplasms Details
Anti-EPCAM CAR-T cell therapy (Zhejiang University) Phase 1 Clinical Zhejiang University Stomach Neoplasms; Pancreatic Neoplasms; Colorectal Neoplasms; Carcinoma, Hepatocellular Details
Oportuzumab monatox 4D5MOCB-ETA; VB4-845; VB-4847; B-4845; VB-845 Phase 3 Clinical Viventia Biotech, Sesen Bio Urinary Bladder Neoplasms Details
ING-1 ING-1 Xoma Details
Solitomab MT-110; AMG-110 Micromet Details
Citatuzumab bogatox VB6-845; VB6-845d Viventia Biotech Details
M-701 M-701 Phase 2 Clinical Wuhan Yzy Biopharma Co Ltd, Cspc-Nbp Pharmaceutical Co Ltd Hydrothorax; Neoplasms; Ascites Details

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