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DPPIV

요약

Name:Dipeptidyl peptidase IV
Target Synonym:Dipeptidyl peptidase IV membrane form,T-cell activation antigen CD26,Adenosine deaminase complexing protein 2,Dipeptidyl peptidase IV,Dipeptidyl peptidase IV soluble form,ADCP2,Dipeptidyl peptidase 4,ADCP-2,ADABP,DPP4,Dipeptidylpeptidase IV (CD26, Adenosine Deaminase Complexing Protein 2),DPP IV,TP103,CD26,Dipeptidyl-Peptidase 4,Dipeptidylpeptidase 4,CD26 Antigen,DPPIV,Xaa-Pro-Dipeptidylaminopeptidase,Gly-Pro Naphthylamidase,Post-Proline Dipeptidyl Aminopeptidase IV
Number of Launched Drugs:33
Number of Drugs in Clinical Trials:24
Lastest Research Phase:Approved

제품 리스트 비교 또는 구매

일부의 생물활성 데이터

DP4-C52H9-SPR
Human_FcRn_Heterodimer_Protein_SPR

MERS S1 protein, His Tag (Cat. No. S1N-M52H5) immobilized on CM5 Chip can bind Cynomolgus DPPIV, His Tag (Cat. No. DP4-C52H9) with an affinity constant of 60.7 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

DP4-H5221-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human DPPIV, His Tag (Cat. No. DP4-H5221) immobilized on CM5 Chip can bind MERS S1 protein, His Tag (Cat. No. S1N-M52H5) with an affinity constant of 0.303 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Synonym Name

DPP4,ADABP,ADCP2,CD26,DPPIV,TP103

Background

Dipeptidyl peptidase-IV (DPPIV) is also known as adenosine deaminase complexing protein 2, DPPIV or CD26 is antigenic enzyme expressed on the surface of most cell types and is associated with immune regulation, signal transduction and apoptosis. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. The substrates of DPPIV are proline (or alanine)-containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides. DPPIV plays a major role in glucose metabolism. It is responsible for the degradation of incretins such as GLP-1. DPPIV plays an important role in tumor biology, and is useful as a marker for various cancers, with its levels either on the cell surface or in the serum increased in some neoplasms and decreased in others. DPPIV also binds the enzyme adenosine deaminase specifically and with high affinity. The significance of this interaction has yet to be established.

Clinical and Translational Updates

공개 약품 정보

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Teneligliptin Hydrobromide Hydrate/Canagliflozin Hemihydrate Approved Mitsubishi Tanabe Pharma Corp, Daiichi Sankyo Co Ltd Canalia Japan Diabetes Mellitus, Type 2 Daiichi Sankyo Co Ltd, Mitsubishi Tanabe Pharma 2017-07-03 Diabetes Mellitus, Type 2 Details
Empagliflozin/Linagliptin/Metformin Approved Boehringer Ingelheim Gmbh, Eli Lilly And Company Trijardy XR United States Diabetes Mellitus, Type 2 Boehringer Ingelheim Gmbh 2020-01-27 Diabetes Mellitus, Type 2 Details
Gemigliptin Approved Details
Alogliptin Benzoate/Pioglitazone Hydrochloride SYR-322-4833 BL Approved Takeda Pharmaceutical Co Ltd Nesinaact, Oseni, Liovel, Incresync EU Diabetes Mellitus, Type 2 Takeda Pharma A/S 2011-07-01 Diabetes Mellitus, Type 2 Details
Anagliptin/Metformin Hydrochloride SK-1501 Approved Sanwa Kagaku Kenkyusho Co Ltd, Suzuken Metoana Japan Diabetes Mellitus, Type 2 Sanwa Kagaku Kenkyusho Co Ltd 2018-09-21 Diabetes Mellitus, Type 2 Details
Dapagliflozin Propanediol Monohydrate/Saxagliptin Hydrochloride Approved Astrazeneca Plc Qtern United States Diabetes Mellitus, Type 2 Astrazeneca Ab 2016-07-15 Diabetes Mellitus, Type 2 Details
Sitagliptin Phosphate Monohydrate/Ipragliflozin L-Proline MK-0431J Approved Merck & Co Inc, Astellas Pharma Inc Sujanu Japan Diabetes Mellitus, Type 2 null 2018-03-23 Diabetes Mellitus, Type 2 Details
Sitagliptin/Ertugliflozin Approved Pfizer Pharmaceuticals Ltd (China) Steglujan EU Diabetes Mellitus, Type 2 Merck Sharp & Dohme Bv 2017-12-19 Diabetes Mellitus, Type 2 Details
Linagliptin/Empagliflozin BI 1356/BI 10773; BI 10773/linagliptin; BI 1356/empagliflozin; Empagliflozin/BI 1356; Linagliptin/BI 10773; BI 10773/BI 1356 Approved C.H. Boehringer Sohn Ag & Co. Kg Tradiance, Glyxambi, Esgliteo United States Cardiovascular Diseases Boehringer Ingelheim Gmbh 2015-01-30 Diabetes Mellitus, Type 2; Cardiovascular Diseases Details
Saxagliptin Hydrochloride/Metformin Hydrochloride Approved Astrazeneca Pharmaceutical Co Ltd 安立格, Komboglyze, Kombiglyze Xr Mainland China Diabetes Mellitus, Type 2 Astrazeneca Ab 2010-11-05 Diabetes Mellitus, Type 2 Details
Linagliptin/Metformin Hydrochloride Approved Boehringer Ingelheim Gmbh 欧双宁, Jentadueto, Trajenta Duo, Jentadueto Xr Mainland China Diabetes Mellitus, Type 2 Boehringer Ingelheim (Schweiz) Gmbh 2012-01-30 Diabetes Mellitus, Type 2 Details
Sitagliptin Phosphate/Metformin Hydrochloride Approved Merck & Co Inc Janumet, Velmetia Mainland China Diabetes Mellitus, Type 2 Msd Pharma (Singapore) Pte Ltd 2007-03-30 Diabetes Mellitus, Type 2 Details
Metformin Hydrochloride/Sitagliptin Hydrochloride Approved Sandoz Bv EU Sandoz Bv 2019-12-10 Details
Sitagliptin Tartrate Approved Heumann Pharma Gmbh & Co. Generica Kg Sitagliptin Heumann 25 mg Filmtabletten EU Heumann Pharma Gmbh & Co. Generica Kg 2020-12-14 Details
Omarigliptin MK-3102 Approved Merck & Co Inc Marizev Japan Diabetes Mellitus, Type 2 Merck Sharp & Dohme Corp 2015-09-28 Diabetes Mellitus, Type 2 Details
Evogliptin Tartrate/Metformin Hydrochloride DA-1229_01 Approved Dong-A Pharmaceutical Co Ltd Sugamet XR South Korea Diabetes Mellitus, Type 2 Dong-A Pharmaceutical Co Ltd 2015-12-01 Diabetes Mellitus, Type 2 Details
Trelagliptin Succinate TAK-472; SYR-472; SYR-111472; SYR-111472 succinate Approved Takeda Pharmaceutical Co Ltd Zafatek Mainland China Diabetes Mellitus, Type 2 Sichuan Kelun Pharmaceutical Co Ltd 2015-03-26 Diabetes Mellitus, Type 2 Details
Anagliptin SK-0403; CWP-0403 Approved Sanwa Kagaku Kenkyusho Co Ltd Suiny, Beskoa Japan Diabetes Mellitus, Type 2 null 2012-09-28 Diabetes Mellitus, Type 2 Details
Vildagliptin/Metformin Hydrochloride LMF-237 Approved Novartis Pharma Ag 宜合瑞, Eucreas, EquMet, Zomarist, Icandra Japan Diabetes Mellitus, Type 2 Novartis Pharma Ag 2007-11-14 Diabetes Mellitus, Type 2 Details
Alogliptin Benzoate SYR-322; TAK-322 Approved Takeda Nesina, 尼欣那, Vipidia EU Diabetes Mellitus, Type 2 Takeda Pharma A/S 2010-04-06 Diabetes Mellitus, Type 2 Details
Rosuvastatin Calcium/Gemigliptin L-tartrate Sesquihydrate Approved Lg Life Sciences Ltd ZemiStatin Diabetes Mellitus, Type 2; Dyslipidemias Details
Teneligliptin Hydrobromide Hydrate MP-513 Approved Mitsubishi Tanabe Pharma Tenelia, Tenglyn Mainland China Diabetes Mellitus, Type 2 Mitsubishi Pharma Research & Development (Beijing) Co Ltd 2012-06-29 Diabetes Mellitus, Type 2 Details
Saxagliptin Hydrate BMS-477118; BMS-477118-11; OPC-262 Approved Bristol-Myers Squibb Company 安立泽, Onglyza Japan Diabetes Mellitus, Type 2 Kyowa Hakko Kirin Co Ltd 2009-07-31 Diabetes Mellitus, Type 2 Details
Teneligliptin Hydrobromide Hydrate/Metformin Hydrochloride Approved Handok Inc Tenelia M SR South Korea Diabetes Mellitus, Type 2 Handok Inc 2015-11-03 Diabetes Mellitus, Type 2 Details
Evogliptin DA-1229 Approved Dong-A Pharmaceutical Co Ltd Suganon, Sugarnon South Korea Diabetes Mellitus, Type 2 Dong-A Pharmaceutical Co Ltd 2015-10-02 Diabetes Mellitus, Type 2 Details
Gemigliptin L-tartrate Sesquihydrate/Metformin Hydrochloride Approved Lg Life Sciences Ltd ZemiMet SR South Korea Diabetes Mellitus, Type 2 Lg Life Sciences Ltd 2015-01-01 Diabetes Mellitus, Type 2 Details
Gemigliptin L-tartrate Sesquihydrate LC-150444; LC-15-0444 Approved Lg Life Sciences Ltd Gemiglo, Zemiglo South Korea Diabetes Mellitus, Type 2 Lg Life Sciences Ltd 2012-06-27 Diabetes Mellitus, Type 2 Details
Teneligliptin/Pioglitazone Approved Glenmark Pharmaceuticals Ltd Zita Plus Pio India Diabetes Mellitus, Type 2 Glenmark Pharmaceuticals Ltd 2022-04-25 Diabetes Mellitus, Type 2 Details
Alogliptin Benzoate/Metformin Hydrochloride CT-L01; CT-L-01 Approved Takeda Pharmaceutical Co Ltd Inisync, Kazano, Vipdomet Japan Diabetes Mellitus, Type 2 Takeda 2013-01-25 Diabetes Mellitus, Type 2 Details
Sitagliptin Hydrochloride Approved EU Diabetes Mellitus, Type 2 Laboratorios Alter Sa 2018-11-27 Diabetes Mellitus, Type 2; Graft vs Host Disease Details
Vildagliptin LAF-237; DSP-7238; LAF-237A; NVP-LAF-237 Approved Novartis Pharma Ag 佳维乐, Equa, Jalra, Galvus, Gliptus, Xiliarx Mainland China Diabetes Mellitus, Type 2 Novartis Europharm Ltd 2007-09-25 Prediabetic State; Diabetes Mellitus, Type 1; Rejection of renal transplantation; Diabetes Mellitus, Type 2; Renal Insufficiency; Schizophrenia; Insulin Resistance; Kidney Diseases; Dyslipidemias; Diabetes, Gestational; Diabetes Mellitus Details
Sitagliptin Phosphate Monohydrate ONO-5435A; ONO-5435; MK-0431; MK-431; L-000224715 Approved Merck Sharp & Dohme Corp Xelevia, Ristaben, Tesavel, Glactiv, 捷诺维, Januvia Japan Diabetes Mellitus, Type 2 Msd Kk 2006-10-16 Graft vs Host Disease; Hyperlipidemias; Kidney Failure, Chronic; Diabetes Mellitus; Inflammation; Lymphoma, Non-Hodgkin; Leukemia, Myeloid, Acute; Cardiovascular Diseases; Hepatic Insufficiency; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Dyslipidemias; Psoriasis; Gastroparesis; Diabetes Mellitus, Type 1; Myelodysplastic Syndromes; Glucose Intolerance; Insulin Resistance; Coronavirus Disease 2019 (COVID-19); Heart Failure; Atherosclerosis; Non-alcoholic Fatty Liver Disease; Diabetes Mellitus, Type 2; Prediabetic State; Cystic Fibrosis; Leukemia, Myelogenous, Chronic, BCR-ABL Positive Details
Linagliptin BI-1356; BI-1356-BS Approved Boehringer Ingelheim Gmbh 欧唐宁, Ondero, Trajenta, Trayenta, Trazenta, Tradjenta Mainland China Diabetes Mellitus, Type 2 Boehringer Ingelheim International Gmbh 2011-05-02 Hypertension; Diabetes Mellitus; Ventricular Dysfunction, Left; Inflammation; Glucose Metabolism Disorders; Hepatic Insufficiency; Metabolic Diseases; Coronavirus Infections; Endocrine System Diseases; Urinary Bladder Neoplasms; Prediabetic State; Coronavirus Disease 2019 (COVID-19); Respiratory Tract Diseases; Carcinoma, Transitional Cell; Schizophrenia; Esophageal Neoplasms; Renal Insufficiency; Albuminuria; Diabetes Mellitus, Type 2 Details

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
TSL-0319 TSL-0319 Phase 1 Clinical Jiangsu Tasly Diyi Pharmaceutical Co Ltd Diabetes Mellitus, Type 2 Details
WXSHC-071 WXSHC-071 Phase 1 Clinical Dongbao Zixing (Hangzhou) Biological Medicine Co Ltd Diabetes Mellitus, Type 2 Details
THDBH-100 THDBH100; THDBH101 Phase 1 Clinical Wuxi Apptec(Shanghai) Co Ltd Diabetes Mellitus, Type 2 Details
Sitagliptin/Telmisartan HDDO-16091 + HDDO-16092; HOB-077; HDDO-1609 Phase 1 Clinical Hyundai Pharmaceutical Hypertension; Diabetes Mellitus Details
REC-04 Clinical Recardio Cardiovascular Diseases Details
Cetagliptin Phosphate CGT-8012 Phase 3 Clinical Cgenetech(Suzhou China) Co Ltd Diabetes Mellitus, Type 2 Details
Fotagliptin Benzoate FCN-005 Phase 3 Clinical Chongqing Fuchuang Pharmaceuticals Research Co Ltd, Shanghai Fosun Pharmaceutical (Group) Co Ltd Diabetes Mellitus, Type 2 Details
TQ-05510 TQ-05510 Phase 1 Clinical Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd, Centaurus Biopharma Co Ltd Diabetes Mellitus, Type 2 Details
Augliptin Hydrochloride Phase 1 Clinical Shanghai Sun-Sail Pharmaceutical Science & Technology Co Ltd, Nanjing Changao Pharmaceutical Science And Technologyco Ltd Diabetes Mellitus, Type 2 Details
Dapagliflozin/Sitagliptin SID-1903; DW-6012 Phase 1 Clinical Astrazeneca Sa Diabetes Mellitus, Type 2 Details
Carmegliptin R-1579; RG-1579; DPP-IV(3); RO-4876904; RO-4876904-001 F. Hoffmann-La Roche Ltd Details
Linagliptin/Fimasartan Potassium Trihydrate Boryung Pharmaceutical Co Ltd Details
Gosogliptin PF-734200; PF-00734200 Pfizer Pharmaceuticals Ltd (China) Details
CPL2009-0031 Cadila Healthcare Ltd Details
KRP-104 KRP-104 Kyorin Pharmaceutical Co Ltd Details
Lobeglitazone/Sitagliptin CKD-396 Chong Kun Dang Pharmaceutical Corp Details
Melogliptin GRC-8200; EMD-675992 Glenmark Pharmaceuticals Ltd Details
BMS-767778 BMS-767778 Bristol-Myers Squibb Company Details
Dutogliptin Tartrate REC-01; PHX-1149; PHX-1149T Phenomix Details
Talabostat (BioXcel) PT-100; BXCL-701 Phase 2 Clinical Inveni Prostatic Neoplasms Details
Diabetes therapeutic DBPR-108 Phase 3 Clinical Taiwan Shenlong Co Ltd, National Health Research Institutes Diabetes Mellitus, Type 2 Details
Dutogliptin Tartrate/Metformin Hydrochloride Phenomix Corporation Details
Evogliptin Tartrate LY-05007 Phase 1 Clinical Dong-A Pharmaceutical Co Ltd Diabetes Mellitus, Type 2 Details
Begelomab SAND-26; BT 5/9 Phase 2 Clinical Adienne Dermatomyositis; Graft vs Host Disease Details
TQ-F3083 TQ-F3083 Phase 2 Clinical Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd, Centaurus Biopharma Co Ltd Diabetes Mellitus, Type 2; Diabetes Mellitus Details
Yogliptin Phase 3 Clinical Sichuan Sunheal Pharmaceutical Co Ltd, Chengdu Easton Biopharmaceuticals Co Ltd Diabetes Mellitus, Type 2 Details
Bogliptin maleate HL012MA Phase 2 Clinical Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences, East China University Of Science And Technology, Shandong Baiji Dichang Pharmaceutical Co Ltd Diabetes Mellitus, Type 2 Details
Retagliptin Phosphate/Metformin Hydrochloride HRX-0701 Phase 1 Clinical Jiangsu Hengrui Medicine Co Ltd Diabetes Mellitus, Type 2 Details
Metformin/Dapagliflozin/Sitagliptin GMRx4 Phase 2 Clinical George Medicines PTY Ltd, George Medicines UK Ltd Diabetes Mellitus, Type 2 Details
DC291407 DC-407; DC-291407 Phase 2 Clinical Cisen Pharmaceutical Co Ltd, Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Diabetes Mellitus, Type 2; Fatty Liver Details
HSK-7653 HSK7653; HSK-7653 Phase 3 Clinical Liaoning Haisco Pharmaceutical Co Ltd, Sichuan Haisco Pharmaceutical Co Ltd Diabetes Mellitus, Type 2; Glucose Intolerance Details

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