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M-CSF R

요약

Name:Colony stimulating factor 1 receptor
Target Synonym:CSFR,CD115 Antigen,FMS Proto-Oncogene,EC 2.7.10.1,CSF1R,Proto-Oncogene C-Fms,Macrophage Colony-Stimulating Factor 1 Receptor,FIM2,McDonough Feline Sarcoma Viral (V-Fms) Oncogene Homolog,CSF-1R,C-FMS,Macrophage Colony Stimulating Factor I Receptor,CD115,HDLS,EC:2.7.10.1,EC 2.7.10,CSF-1-R,CSF-1 Receptor,FMS,BANDDOS,M-CSF-R,Colony Stimulating Factor 1 Receptor
Number of Launched Drugs:8
Number of Drugs in Clinical Trials:37
Lastest Research Phase:Approved

제품 리스트 구매

일부의 생물활성 데이터

CSR-H5258-SPR
 M-CSF R SPR

Human M-CSF Protein, His Tag (Cat. No. MCF-H5247) captured on CM5 Chip via anti-His antibody can bind Human M-CSF R Protein, Fc Tag (Cat. No. CSR-H5258) with an affinity constant of 1.9 nM as determined in SPR assay (Biacore T200) (Routinely tested).

CSR-H5228-SPR
 M-CSF R SPR

Biotinylated Human M-CSF, His,Avitag (Cat. No. MCF-H82E6) immobilized on SA Chip can bind Human M-CSF R, His Tag (Cat. No. CSR-H5228) with an affinity constant of 0.309 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

Synonym Name

CSF1R,C-FMS,CD115,CSFR,FIM2,FMS,M-CSFR

Background

Colony stimulating factor 1 receptor (CSF1R) is also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR,  FIM2, FMS, and is a member of the typeⅢ subfamily of receptor tyrosine kinases (RTKs). CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation . Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.

Clinical and Translational Updates

Related Molecule

공개 약품 정보

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
pacritinib citrate SB-1518; ONX-0803 Approved S*BIO Pte Ltd, Concert VONJO United States Primary Myelofibrosis Cti Biopharma Corp 2022-02-28 Hepatic Insufficiency; Carcinoma, Non-Small-Cell Lung; Thrombocythemia, Essential; Leukemia, Lymphocytic, Chronic, B-Cell; Sarcoma, Kaposi; Thrombocytopenia; Lymphoma, T-Cell; Lymphoma; Lymphoma, Non-Hodgkin; Leukemia, Myelomonocytic, Juvenile; Lymphoma, T-Cell, Cutaneous; Leukemia, Myeloid, Acute; Waldenstrom Macroglobulinemia; Colorectal Neoplasms; Lymphoproliferative Disorders; Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative; Lymphoma, T-Cell, Peripheral; Primary Myelofibrosis; Castleman Disease; Coronavirus Infections; Lymphoma, Mantle-Cell; Myelodysplastic Syndromes; Coronavirus Disease 2019 (COVID-19); Graft vs Host Disease; Hodgkin Disease; Myeloproliferative Disorders; Leukemia, Myelomonocytic, Chronic; Polycythemia Vera; Lymphoma, B-Cell; Leukemia, Myelogenous, Chronic; Leukemia Details
Sunitinib Malate PHA-290940; SU-010398; SU-11248; GB-102; PNU-290940; SU-011248-L-malate salt; PNU-290940AD; PHA-290940AD; SCAI-003 Approved Pfizer Pharmaceuticals Ltd (China) Sutent, 索坦 United States Gastrointestinal Stromal Tumors; Carcinoma, Renal Cell Cppi Cv 2006-01-26 Solid tumours; Lymphoma, B-Cell; Lymphoma, B-Cell, Marginal Zone; Leiomyosarcoma; Fibrosarcoma; Leukemia; Kidney Neoplasms; Teratoma; Head and Neck Neoplasms; HIV Infections; Intestinal Neoplasms; Ovarian Neoplasms; Ependymoma; Leukemia, Myeloid, Accelerated Phase; Fibromatosis, Aggressive; Liver Neoplasms; Lymphoma, T-Cell, Peripheral; Leukemia, Myelogenous, Chronic; Carcinoma, Renal Cell; Pheochromocytoma; Histiocytoma, Malignant Fibrous; Thoracic Neoplasms; Hemangioblastoma; Leukemia, Hairy Cell; Abdominal Neoplasms; Stomach Neoplasms; Carcinoma, Islet Cell; Polycythemia Vera; Esophageal Neoplasms; Carcinoma; Pelvic Neoplasms; Squamous Cell Carcinoma of Head and Neck; Glioblastoma; Myelodysplastic Syndromes; Carcinoma, Papillary; Hodgkin Disease; Lymphoma, Large B-Cell, Diffuse; Leukemia, Myelomonocytic, Chronic; Neurofibromatoses; Pancreatic neuroendocrine tumors (pNET); Neoplasms; Adenoma, Islet Cell; Myeloproliferative Disorders; Pancreatic Neoplasms; Plasmacytoma; Carcinoma, Transitional Cell; Immunogl Details
Pexidartinib PLX-3397 Approved Daiichi Sankyo Co Ltd Turalio United States Giant Cell Tumor of Tendon Sheath Daiichi Sankyo Inc 2019-08-02 Neurofibrosarcoma; Carcinoma, Non-Small-Cell Lung; Melanoma; Neoplasm Metastasis; Leukemia, Myeloid, Acute; Gastrointestinal Stromal Tumors; Colorectal Neoplasms; Giant Cell Tumors; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Neurofibroma, Plexiform; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms; Sarcoma; Solid tumours; Breast Neoplasms; Neoplasms; Arthritis, Rheumatoid; Hodgkin Disease; Glioblastoma; Pancreatic Neoplasms; Synovitis, Pigmented Villonodular; Squamous Cell Carcinoma of Head and Neck; Leukemia, Promyelocytic, Acute; Ovarian Neoplasms; Giant Cell Tumor of Tendon Sheath Details
Nintedanib Esylate BIBF-1120 Approved C.H. Boehringer Sohn Ag & Co. Kg Ofev, Vargatef United States Idiopathic Pulmonary Fibrosis Boehringer Ingelheim Gmbh 2014-10-15 Carcinoma, Squamous Cell; Sarcoma; Prostatic Neoplasms; systemic sclerosis-associated interstitial lung disease; Adenocarcinoma, Clear Cell; Colorectal Neoplasms; Peritoneal Neoplasms; Astrocytoma; Genital Neoplasms, Female; Hepatic Insufficiency; Silicosis; Gliosarcoma; Breast Neoplasms; Lung Neoplasms; Appendiceal Neoplasms; Fallopian Tube Neoplasms; Leukemia, Myeloid, Acute; Uterine Neoplasms; Endometrial Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Carcinoma, Endometrioid; Adenocarcinoma; Glioblastoma; Telangiectasia, Hereditary Hemorrhagic; Solid tumours; Radiation Pneumonitis; Esophageal Neoplasms; Rejection of lung transplantation; Carcinoma, Renal Cell; Carcinoid Tumor; Endometrial Stromal Tumors; Colonic Neoplasms; Idiopathic Pulmonary Fibrosis; Ovarian Neoplasms; Scleroderma, Systemic; Neoplasms; Small Cell Lung Carcinoma; Lung Diseases, Interstitial; Mesothelioma; Pulmonary Fibrosis; Multiple Myeloma; Asbestosis; Oligodendroglioma; Neuroendocrine Tumors Details
Mirimostim P-100; CSF-HU Approved Jcr Pharmaceuticals Co Ltd Costilate, Leukoprol Japan Neutropenia Jcr Pharmaceuticals Co Ltd 1991-01-01 Neutropenia Details
Surufatinib HMPL-012 Approved Hutchison Medipharma Ltd 苏泰达, SULANDA Mainland China Neuroendocrine Tumors Hutchison Medipharma Ltd 2020-12-29 Hematologic Neoplasms; Solid tumours; Biliary Tract Neoplasms; Intestinal Neoplasms; Neoplasms; Small Cell Lung Carcinoma; Pancreatic neuroendocrine tumors (pNET); Kidney Diseases; Neuroendocrine Tumors; Sarcoma; Bile Duct Neoplasms; Hepatic Insufficiency; Carcinoma, Neuroendocrine; Appendiceal Neoplasms; Thyroid Neoplasms Details
Regorafenib DAST; BAY-73-4506 Approved Bayer AG Stivarga, Resihance United States Colorectal Neoplasms Bayer Healthcare Pharmaceuticals Inc 2012-09-27 Esophageal adenocarcinoma; Osteosarcoma; Sarcoma, Ewing; Bile Duct Neoplasms; Peritoneal Neoplasms; Bone Neoplasms; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Fallopian Tube Neoplasms; Lung Neoplasms; Thyroid Neoplasms; Sarcoma; Leukemia, Myeloid, Acute; Thymoma; Melanoma; Gastrointestinal Neoplasms; Carcinoma, Hepatocellular; Adenocarcinoma; Somatostatinoma; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Solid tumours; Liver Neoplasms; Carcinoid Tumor; Esophageal Neoplasms; Stomach Neoplasms; Carcinoma, Islet Cell; Insulinoma; Hemangiosarcoma; Rectal Neoplasms; Carcinoma, Renal Cell; Ovarian Neoplasms; Pancreatic Neoplasms; Colonic Neoplasms; Neoplasms; Glioblastoma; Carcinoma, Transitional Cell; Glucagonoma; Carcinoma, Adenoid Cystic; Adenoma; Gastrinoma Details
Pazopanib Hydrochloride GSK-786034; GW-786034B; SB-786034; GW-786034 Approved Glaxosmithkline Plc, Novartis Pharma Ag 维全特, Armala, Votrient, Patorma United States Carcinoma, Renal Cell; Sarcoma Novartis Pharma Ag 2009-10-19 Uterine Cervical Diseases; Fallopian Tube Neoplasms; Lung Neoplasms; Uterine Neoplasms; Choriocarcinoma; Lymphoma; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Carcinoma, Mucoepidermoid; Gliosarcoma; Genital Neoplasms, Female; Leukemia, Myeloid, Acute; Peritoneal Neoplasms; Brain Neoplasms; Urethral Neoplasms; Medullary thyroid cancer (MTC); Chondrosarcoma, Extraskeletal Myxoid; Prostatic Neoplasms; Osteosarcoma; Neuroblastoma; Sarcoma; Breast Neoplasms; Carcinoma, Hepatocellular; Uterine Cervical Neoplasms; Breast Neoplasms, Male; Neoplasm Metastasis; von Hippel-Lindau Disease; Thyroid Cancer, Papillary; Gastrointestinal Neoplasms; Paraganglioma; Endodermal Sinus Tumor; Neoplasms, Germ Cell and Embryonal; Melanoma; Gastrinoma; Macular Degeneration; Carcinoma, Non-Small-Cell Lung; Thyroid Neoplasms; Carcinoma, Squamous Cell; Carcinoma, Small Cell; Carcinoma, Embryonal; Germinoma; Glioma; Carcinoma, Neuroendocrine; Epistaxis; Carcinoma, Ovarian Epithelial; Neoplasms; Squamous Cell Carcinoma of Head a Details

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
EI-1071 EI-1071; FB-1071 Phase 1 Clinical Elixiron Immunotherapeutics Inc Giant Cell Tumor of Tendon Sheath; Alzheimer Disease; Nervous System Diseases; Amyotrophic Lateral Sclerosis Details
SYHA-1813 SYHA1813 Phase 1 Clinical Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences, Shanghai Runshi Pharmaceutical Technology Co Ltd Solid tumours; Giant Cell Tumor of Tendon Sheath; Carcinoma, Renal Cell; Stomach Neoplasms; Gliosarcoma; Colorectal Neoplasms; Brain metastases; Thyroid Neoplasms; Lung Neoplasms; Glioma Details
Chiauranib CS-2164 Phase 3 Clinical Shenzhen Chipscreen Biosciences Co Ltd Solid tumours; Ovarian Neoplasms; Small Cell Lung Carcinoma; Neoplasms; Triple Negative Breast Neoplasms; Sarcoma; Lymphoma, Non-Hodgkin; Carcinoma, Hepatocellular Details
TT-00420/Atezolizumab Phase 1 Clinical TransThera Sciences (Nanjing) Inc Gastrointestinal Neoplasms Details
Cabiralizumab FPA-008; ONO-4687; BMS-986227 Phase 2 Clinical Five Prime Therapeutics Inc Solid tumours; Head and Neck Neoplasms; Ovarian Neoplasms; Giant Cell Tumor of Tendon Sheath; Carcinoma, Renal Cell; Synovitis, Pigmented Villonodular; Triple Negative Breast Neoplasms; Neoplasms; Pancreatic Neoplasms; Arthritis, Rheumatoid; Glioma; Carcinoma, Non-Small-Cell Lung Details
Recombinant human GM-CSF oncolytic herpes simplex virus type 2 (OH2) BS-001; oHSV-2; OH-2 Phase 3 Clinical Wuhan Binhui Biotechnology Co Ltd Central Nervous System Neoplasms; Melanoma; Lymphoma; Lung Neoplasms; Colorectal Neoplasms; Bile Duct Neoplasms; Breast Neoplasms; Sarcoma; Digestive System Neoplasms; Liver Neoplasms; Liver Diseases; Urinary Bladder Neoplasms; Neoplasms; Pancreatic Neoplasms; Esophageal Neoplasms; Solid tumours; Head and Neck Neoplasms Details
Edicotinib JNJ-244; JNJ-527; PRV-6527; JNJ-40346527 Phase 2 Clinical Johnson & Johnson Hodgkin Disease; Arthritis, Rheumatoid; Cognitive Dysfunction; Alzheimer Disease; Leukemia, Myeloid, Acute; Crohn Disease Details
Pamufetinib TAS-115 Phase 1 Clinical Taiho Pharmaceutical Co Ltd, Otsuka Pharmaceutical Co Ltd Neoplasms Details
Elzovantinib TPX-0022 Phase 2 Clinical Solid tumours; Stomach Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis Details
[11C]CPPC Phase 2 Clinical Johns Hopkins University Amyotrophic Lateral Sclerosis Details
C-019199 C019199 Phase 2 Clinical Solid tumours Details
AMG-820 AMG-820 Phase 2 Clinical Amgen Inc Solid tumours; Neoplasms; Pancreatic Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Emactuzumab RG-7155; 6FY6EI1X8R; RO-5509554 Phase 3 Clinical F. Hoffmann-La Roche Ltd Solid tumours; Head and Neck Neoplasms; Carcinoma; Neoplasms; Prostatic Neoplasms; Testicular Neoplasms; Lymphoma, Non-Hodgkin; Carcinoma, Squamous Cell Details
JDB-383 JDB-383 Phase 1 Clinical Shanghai Jiabao Yaoyin Pharmaceutical Technology Co Ltd Giant Cell Tumor of Tendon Sheath Details
Nintedanib Solution for Inhalation AP02; AP-02 Phase 1 Clinical Avalyn Pharma Inc Idiopathic Pulmonary Fibrosis Details
Simmitinib hydrochloride SOMCL-15-290 Phase 2 Clinical Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Solid tumours Details
Axatilimab SNDX-6352; UCB-6352; INCA-34176 Phase 2 Clinical Ucb Cytokine Release Syndrome; Solid tumours; Graft vs Host Disease; Hodgkin Disease; Idiopathic Pulmonary Fibrosis; Triple Negative Breast Neoplasms; Neoplasms; Respiratory Distress Syndrome, Adult; Cholangiocarcinoma; Breast Neoplasms; Coronavirus Infections; Neoplasm Metastasis Details
Pimicotinib ABSK-021 Phase 3 Clinical ABbisko Therapeutics Co Ltd Giant Cell Tumor of Tendon Sheath; Solid tumours; Synovitis, Pigmented Villonodular; Triple Negative Breast Neoplasms; Pancreatic Neoplasms; Neoplasms; Graft vs Host Disease; Sarcoma; Lung Neoplasms; Amyotrophic Lateral Sclerosis Details
AMB-05X AMB-05X Phase 2 Clinical Amgen Inc Giant Cell Tumor of Tendon Sheath; Synovitis, Pigmented Villonodular; Idiopathic Pulmonary Fibrosis; Testicular Neoplasms Details
ETH-155036 ETH-155036; ETH155036 Phase 1 Clinical Shengke Pharmaceutical (Jiangsu) Co Ltd Myelodysplastic Syndromes; Leukemia, Myeloid, Acute Details
Vimseltinib DCC-3014 Phase 3 Clinical Deciphera Giant Cell Tumor of Tendon Sheath; Synovitis, Pigmented Villonodular; Neoplasms Details
Sotuletinib BLZ-945 Phase 2 Clinical Novartis Pharma Ag, Celgene Corp Solid tumours; Amyotrophic Lateral Sclerosis Details
Caflanone FBL-03G Phase 1 Clinical Flavocure Biotech Inc Pancreatic Neoplasms Details
LY-3022855 IMC-CS4; LY-3022855 Phase 2 Clinical Eli Lilly And Company Solid tumours; Pancreatic Neoplasms; Neoplasms; Neoplasm Metastasis; Melanoma Details
PMI-04 Phase 1 Clinical Nerve Degeneration Details
Derazantinib ARQ-087.2HCl; AQ-14741087; ARQ-087; BAL-087 Phase 2 Clinical Arqule Inc Biliary Tract Neoplasms; Solid tumours; Stomach Neoplasms; Carcinoma, Transitional Cell; Cholangiocarcinoma; Urogenital Neoplasms; Carcinoma, Hepatocellular Details
APL-102 APL-102; CBT-102 Phase 1 Clinical Apollomics Inc Solid tumours Details
HMPL-653 HMPL-653 Phase 1 Clinical Hutchison Medipharma Ltd Giant Cell Tumor of Tendon Sheath; Solid tumours; Testicular Neoplasms Details
AGX-0073 AGX-0073 Phase 1 Clinical Shanghai Aojian Biological Technology Co Ltd Solid tumours Details
Q-702 Q-702 Phase 2 Clinical Vichem Chemie, Max Planck Institute of Biochemistry, Lead Discovery Center GmbH Solid tumours; Liver Neoplasms; Esophageal Neoplasms; Stomach Neoplasms; Neoplasms; Neoplasm Metastasis; Uterine Cervical Neoplasms Details
SYHA-1817 SYHA-1817 Phase 1 Clinical CSPC Pharmaceutical Group Ltd Biliary Tract Neoplasms; Stomach Neoplasms; Carcinoma, Squamous Cell Details
BC-006 BC-006; BC006 Phase 1 Clinical Dragonboat Biopharmaceutical Solid tumours; Giant Cell Tumor of Tendon Sheath Details
NMS-03592088 NMS-P088; NMS-03592088 Phase 2 Clinical Nerviano Medical Sciences Srl Leukemia, Myelomonocytic, Chronic; Leukemia, Myeloid, Acute Details
Tinengotinib TT-00420; TT 00420; TT00420 Phase 3 Clinical TransThera Sciences (Nanjing) Inc Solid tumours; Biliary Tract Neoplasms; Stomach Neoplasms; Triple Negative Breast Neoplasms; Small Cell Lung Carcinoma; Urinary Bladder Neoplasms; Cholangiocarcinoma; Prostatic Neoplasms; Breast Neoplasms; Sarcoma; Thyroid Neoplasms; Gallbladder Neoplasms Details
HH185 3D-185; 3-D185; HH-185; 3D185 Phase 2 Clinical ShangHai HaiHe Biopharma Co Ltd, Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences, Shanghai Medicilon Inc Solid tumours; Cholangiocarcinoma Details

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