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Project Name | Project Stage | Molecule Type | Host Species | Therapeutic Area | Indications |
CLDN6 mAb - 01 | PCC | Solid Tumor | Ovarian cancer,Lung adenocarcinoma |
2e5 of anti-Claudin-6 CAR-293 cells were stained with 100 μL of 1 μg/mL of Fluorescent Human Claudin-6 Protein, Flag,His,GFP Tag (Cat. No.CL6-HF2M9) and negative control protein respectively (Fig. A and B), FITC signal was used to evaluate the binding activity (QC tested).
Anti-Claudin 6 antibody, Human IgG1 captured on Protein A Chip can bind Biotinylated Human Claudin-6 Protein, His,Avitag&Flag Tag (Cat. No. CL6-H85D3) with an affinity constant of 41.5 nM as determined in a SPR assay (in presence of DDM and CHS) (Biacore 8K) (Routinely tested).
Name | Research Code | Research Phase | Company | Indications | Clinical Trials |
---|---|---|---|---|---|
IMAB-027 | ASP-1650; IMAB-027 | Phase 2 Clinical | Ganymed | Ovarian Neoplasms; Neoplasms; Neoplasms, Germ Cell and Embryonal | Details |
BNT-142 | BNT-142 | Phase 2 Clinical | Biontech Se | Solid tumours | Details |
NBL-028 | NBL028; NBL-028 | Phase 1 Clinical | Shanghai Xinshi Biological Medicine Co Ltd, Novarock Biotherapeutics Ltd | Solid tumours; Ovarian Neoplasms; Stomach Neoplasms; Neoplasms; Testicular Neoplasms; Endometrial Neoplasms; Carcinoma, Non-Small-Cell Lung | Details |
XmAb-541 | XmAb541; XmAb-541 | Phase 1 Clinical | Xencor Inc | Ovarian Neoplasms; Ovarian germ cell tumor; Germinoma; Endometrial Neoplasms; Neoplasms, Germ Cell and Embryonal | Details |
CLDN6-CAR-NK Cell Therapy | Phase 1 Clinical | Second Affiliated Hospital Of Guangzhou Medical University | Ovarian Neoplasms; Testicular Neoplasms; Endometrial Neoplasms | Details | |
DS-9606a | DS-9606a; DS-9606-a | Phase 1 Clinical | Daiichi Sankyo Inc | Ovarian Neoplasms; Neoplasms; Neoplasm Metastasis; Neoplasms, Germ Cell and Embryonal | Details |
AMG-794 | AMG-794 | Phase 1 Clinical | Amgen Inc | Carcinoma, Ovarian Epithelial; Carcinoma, Non-Small-Cell Lung | Details |
TORL-1-23 | TORL-1-23 | Phase 1 Clinical | Torl Biotherapeutics LLC | Solid tumours; Ovarian Neoplasms; Endometrial Neoplasms; Carcinoma, Non-Small-Cell Lung | Details |
CLDN6 CAR-T cell therapy (BioNTech) | BNT-211 | Phase 1 Clinical | Biontech Se | Solid tumours | Details |
IMAB-027 | ASP-1650; IMAB-027 | Phase 2 Clinical | Ganymed | Ovarian Neoplasms; Neoplasms; Neoplasms, Germ Cell and Embryonal | Details |
BNT-142 | BNT-142 | Phase 2 Clinical | Biontech Se | Solid tumours | Details |
NBL-028 | NBL028; NBL-028 | Phase 1 Clinical | Shanghai Xinshi Biological Medicine Co Ltd, Novarock Biotherapeutics Ltd | Solid tumours; Ovarian Neoplasms; Stomach Neoplasms; Neoplasms; Testicular Neoplasms; Endometrial Neoplasms; Carcinoma, Non-Small-Cell Lung | Details |
XmAb-541 | XmAb541; XmAb-541 | Phase 1 Clinical | Xencor Inc | Ovarian Neoplasms; Ovarian germ cell tumor; Germinoma; Endometrial Neoplasms; Neoplasms, Germ Cell and Embryonal | Details |
CLDN6-CAR-NK Cell Therapy | Phase 1 Clinical | Second Affiliated Hospital Of Guangzhou Medical University | Ovarian Neoplasms; Testicular Neoplasms; Endometrial Neoplasms | Details | |
DS-9606a | DS-9606a; DS-9606-a | Phase 1 Clinical | Daiichi Sankyo Inc | Ovarian Neoplasms; Neoplasms; Neoplasm Metastasis; Neoplasms, Germ Cell and Embryonal | Details |
AMG-794 | AMG-794 | Phase 1 Clinical | Amgen Inc | Carcinoma, Ovarian Epithelial; Carcinoma, Non-Small-Cell Lung | Details |
TORL-1-23 | TORL-1-23 | Phase 1 Clinical | Torl Biotherapeutics LLC | Solid tumours; Ovarian Neoplasms; Endometrial Neoplasms; Carcinoma, Non-Small-Cell Lung | Details |
CLDN6 CAR-T cell therapy (BioNTech) | BNT-211 | Phase 1 Clinical | Biontech Se | Solid tumours | Details |
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