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PTK7

요약

Name:Protein-tyrosine kinase 7
Target Synonym:Colon carcinoma kinase 4,Inactive tyrosine-protein kinase 7,Tyrosine-protein kinase-like 7,CCK-4,PTK7,Protein Tyrosine Kinase 7 (Inactive),Pseudo Tyrosine Kinase Receptor 7,PTK7 Protein Tyrosine Kinase 7,CCK4,Protein-Tyrosine Kinase 7,Protein Tyrosine Kinase 7
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 1 Clinical

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일부의 생물활성 데이터

PT7-R52H6-MALS-HPLC
Rat PTK7, His Tag (Cat. No. ) MALS images

The purity of Rat PTK7, His Tag (Cat. No. PT7-R52H6) is more than 90% and the molecular weight of this protein is around 85-115 kDa verified by SEC-MALS.

  • Background
    PTK7, highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

    PT7-C52H3-MALS-HPLC
    Cynomolgus / Rhesus macaque PTK7, His Tag (Cat. No. ) MALS images

    The purity of Cynomolgus / Rhesus macaque PTK7, His Tag (Cat. No. PT7-C52H3) is more than 85% and the molecular weight of this protein is around 80-116 kDa verified by SEC-MALS.

Synonym Name

PTK7,CCK4,CCK-4,Tyrosine-protein kinase-like 7,Protein-tyrosine kinase 7,Protein-tyrosine kinase 7

Background

PTK7, highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.

Clinical and Translational Updates

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
Cofetuzumab Pelidotin PTK7-ADC; PF-6647020; PF-06647020; PF-7020; hu-24; ABBV-647; Anti-PTK7 ADC; h6M24-vc0101; PF-06523435 Phase 1 Clinical Abbvie Inc, Stemcentrx Neoplasms; Carcinoma, Non-Small-Cell Lung Details

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