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PTK7

요약

Name:Protein-tyrosine kinase 7
Target Synonym:Colon carcinoma kinase 4,Inactive tyrosine-protein kinase 7,Tyrosine-protein kinase-like 7,CCK-4,PTK7,Protein Tyrosine Kinase 7 (Inactive),Pseudo Tyrosine Kinase Receptor 7,PTK7 Protein Tyrosine Kinase 7,CCK4,Protein-Tyrosine Kinase 7,Protein Tyrosine Kinase 7
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

제품 리스트 구매

일부의 생물활성 데이터

PT7-M5256-MALS-HPLC
PTK7 MALS images

The purity of Mouse PTK7 Protein, Fc Tag (Cat. No. PT7-M5256) is more than 90% and the molecular weight of this protein is around 240-270 kDa verified by SEC-MALS.

PT7-H82F5-MALS-HPLC
PTK7 MALS images

The purity of Biotinylated Human PTK7 protein, Fc,Avitag (Cat. No. PT7-H82F5) is more than 90% and the molecular weight of this protein is around 235-265 kDa verified by SEC-MALS.

사용자 리뷰

Synonym Name

PTK7,CCK4,CCK-4,Tyrosine-protein kinase-like 7,Protein-tyrosine kinase 7,Protein-tyrosine kinase 7

Background

PTK7, highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.

Clinical and Translational Updates

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
PRO-1107 PRO-1107 Phase 2 Clinical ProfoundBio (Suzhou) Co Ltd Solid tumours; Ovarian Neoplasms; Esophageal Neoplasms; Stomach Neoplasms; Carcinoma, Transitional Cell; Triple Negative Breast Neoplasms; Endometrial Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Cofetuzumab Pelidotin PF-06647020; PF-6647020; PTK7-ADC; PF-06523435; PF-7020; hu-24; ABBV-647; Anti-PTK7 ADC; h6M24-vc0101 Phase 1 Clinical Stemcentrx Inc, Abbvie Inc Neoplasms; Carcinoma, Non-Small-Cell Lung Details

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