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Your Position: 홈 > ZNRF3

ZNRF3

요약

Name:E3 ubiquitin-protein ligase ZNRF3
Target Synonym:
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 1 Clinical

제품 리스트 구매

제품> 결과 필터링
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제품번호 종 제품 설명 구조 순도 특징
ZN3-H52H3 Human Human ZNRF3 protein, His Tag (MALS verified)
ZN3-H52H3-structure
ZN3-H52H3-sds

일부의 생물활성 데이터

ZN3-H52H3-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human ZNRF3, His Tag (Cat. No. ZN3-H52H3) on HISIK Biosensor, can bind Human R-Spondin 3 Protein, Fc Tag with an affinity constant of 16.05 nM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).

Protocol
ZN3-H52H3-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human R-Spondin 3 Protein, Fc Tag on Protein A Biosensor, can bind Human ZNRF3, His Tag (Cat. No. ZN3-H52H3) with an affinity constant of 10.9 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

Synonym Name

ZNRF3,  Zinc/RING finger protein 3, RING-type E3 ubiquitin transferase ZNRF3, RING finger protein 203, KIAA1133, RNF203

Background

The transmembrane E3 ubiquitin ligase zinc and ring finger 3 (ZNRF3) is a negative feedback regulator of Wnt signalling. ZNRF3 is associated with the Wnt receptor complex, and inhibits Wnt signalling by promoting the turnover of frizzled and LRP6 and acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway.

Clinical and Translational Updates

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
SZN-043 SZN-043; SZN-043双特异性融合蛋白; SZN-043 Bispecific Fusion Protein; SZN-043 (RSPO模拟物) Phase 1 Clinical Surrozen Inc Hepatitis, Alcoholic; Liver Cirrhosis Details

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