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NOTCH3

요약

Name:Neurogenic locus notch homolog protein 3
Target Synonym:Neurogenic Locus Notch Homolog Protein 3,LMNS,Notch 3,NOTCH3,Notch (Drosophila) Homolog 3,Notch Homolog 3 (Drosophila),Notch Homolog 3,CADASIL1,CADASIL,CASIL,IMF2,Receptor, Notch3,Notch Receptor 3
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Preclinical

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제품번호 제품 설명 구조 순도 특징
NO3-H5255 Human Human NOTCH3 Protein, Fc Tag
NO3-H5255-structure
NO3-H5255-sds

일부의 생물활성 데이터

NO3-H5255-MALS-HPLC
Human NOTCH3, Fc TagHuman NOTCH3, Fc Tag (Cat. No. NO3-H5255) ELISA bioactivity

Immobilized Human NOTCH3, Fc Tag (Cat. No. NO3-H5255) at 1 μg/mL (100 μL/well) can bind Bispecific Antibody (NOTCH2 × NOTCH3) with a linear range of 2-20 ng/mL (QC tested).

Synonym Name

Notch-3,NOTCH3

Background

Notch3 is one of four mammalian Notch proteins, which act as signalling receptors and involve in developmental patterning, cell fate decisions, regulation of cell survival and proliferation. Notch3 could interact with membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Via ligand activation, notch intracellular domain (NICD) is released and forms a transcriptional activator RBPJ/RBPSUH complex, which activates genes of the enhancer of split locus. Consequently, the activation of Notch3 can lead to the implementation of differentiation, proliferation and apoptotic programs

Clinical and Translational Updates

    임상 약품 정보

    Name Research Code Research Phase Company Indications Clinical Trials
    Tarextumab OMP-59R5 Oncomed Pharmaceuticals Inc Details
    PF-06650808 PF-6650808; PF-06650808 Pfizer Inc Details

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