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Your Position: > IL-2 R beta & IL-2 R gamma

IL-2 R beta & IL-2 R gamma

요약

Name:Interleukin-2 receptor beta chain
Target Synonym:IL2RB,IMD63,IL-2RB,p75,CD122,Interleukin 2 Receptor Subunit Beta,Interleukin-15 Receptor Subunit Beta,Interleukin 15 Receptor, Beta,Interleukin 2 Receptor, Beta,IL-2R Subunit Beta,CD122 Antigen,P70-75,IL15RB,High Affinity IL-2 Receptor Beta Subunit,Interleukin-2 Receptor beta Subunit,Interleukin-2 receptor subunit beta,IL-2 receptor subunit beta,High affinity IL-2 receptor subunit beta
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:15
Lastest Research Phase:Phase 3 Clinical

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IL-2 R beta & IL-2 R gamma Molecule Synonym Name

IL-2 R beta & IL-2 R gamma,IL-2RB & IL-2RG

IL-2 R beta & IL-2 R gamma Molecule Background

Both Interleukin-2 receptor subunit beta and Interleukin-2 receptor subunit gamma are receptor for interleukin-2. Common subunit for the receptors for a variety of interleukins. Interacts with SHB upon interleukin stimulation. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.

IL-2 R beta & IL-2 R gamma References

임상 약품 정보

Name Research Code Research Phase Company Indications Clinical Trials
Bempegaldesleukin BMS-986321; ONO-7911; NKTR-214 Phase 3 Clinical Nektar Therapeutics Coronavirus Disease 2019 (COVID-19); Melanoma; Neoplasm Metastasis; Lymphoma; Glioma; Sarcoma, Ewing; Brain Neoplasms; Neuroblastoma; Prostatic Neoplasms, Castration-Resistant; Urinary Bladder Neoplasms; Solid tumours; Neoplasms; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Leukemia; Medulloblastoma; Rhabdomyosarcoma; Head and Neck Neoplasms; Ependymoma; Skin Melanoma Details
GI-101 SIM-323; SIM323; SIM0323; GI-101 Phase 2 Clinical GI Innovation Inc Solid tumours; Squamous Cell Carcinoma of Head and Neck; Vaginal Neoplasms; Carcinoma, Merkel Cell; Carcinoma, Renal Cell; Neoplasms; Urinary Bladder Neoplasms; Vulvar Neoplasms; Sarcoma; Colorectal Neoplasms; Esophageal Squamous Cell Carcinoma; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Melanoma Details
Pegenzileukin THOR-707; SAR-444245 Phase 2 Clinical Synthorx Inc Colorectal Neoplasms; Melanoma; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Carcinoma, Squamous Cell; Esophageal Squamous Cell Carcinoma; Esophageal adenocarcinoma; Oropharyngeal Neoplasms; Intestinal Neoplasms; Multiple Myeloma; Mesothelioma; Lymphoma, Large B-Cell, Diffuse; Skin Neoplasms; Hodgkin Disease; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Head and Neck Neoplasms Details
IPH-6501 IPH-6501; IPH-65 Phase 2 Clinical Innate Pharma SA Neoplasms; Lymphoma, Non-Hodgkin Details
LTC-004 LTC004; LTC-004 Phase 2 Clinical Leto Laboratories Co Ltd Solid tumours; Pancreatic Neoplasms; Neoplasms; Sarcoma; Colorectal Neoplasms Details
IAP-0971 IAP-0971 Phase 2 Clinical SunHo (China) BioPharmaceutical Co Ltd Solid tumours; Neoplasms; Urinary Bladder Neoplasms; Carcinoma, Non-Small-Cell Lung Details
TransCon IL-2 β/γ Phase 2 Clinical Ascendis Pharma A/S Ovarian Neoplasms; Solid tumours; Head and Neck Neoplasms; Carcinoma, Non-Small-Cell Lung Details
MDNA-11 MDNA-11; MDNA11 Phase 2 Clinical Medicenna Therapeutics Corp Triple Negative Breast Neoplasms; Uterine Cervical Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung; Endometrial Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Squamous Cell; Peritoneal Neoplasms; Urinary Bladder Neoplasms; Mesothelioma; Skin Neoplasms; Skin Melanoma; Carcinoma, Ovarian Epithelial; Mismatch Repair Deficient Cancer; Stomach Neoplasms; Esophageal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Basal Cell; Carcinoma, Renal Cell; Carcinoma, Merkel Cell; Ovarian Neoplasms; Solid tumours Details
Simlukafusp alfa FAP-IL2v; RG-7461; aFAP-IL2v; RO-6874281; FAP-IL2v FP Phase 1 Clinical F. Hoffmann-La Roche Ltd Head and Neck Neoplasms; Solid tumours; Esophageal Neoplasms; Carcinoma, Renal Cell; Breast Neoplasms; Uterine Cervical Neoplasms; Melanoma Details
BJ-001(Boji Biomedical Technology) BJ-001 Phase 1 Clinical Boji Biomedical Technology (Hangzhou) Co Ltd Solid tumours; Communicable Diseases; Neoplasm Metastasis Details
STK-009 STK-009 Phase 1 Clinical Synthekine Inc Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lupus Nephritis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Mantle-Cell; Lymphoma, Follicular; Lupus Erythematosus, Systemic; Lymphoma, Non-Hodgkin; Leukemia, Lymphocytic, Chronic, B-Cell Details
FB-102 FB-102; FB102 Phase 1 Clinical Forte Biosciences Inc Alopecia Areata; Graft vs Host Disease; Vitiligo; Malabsorption Syndromes Details
NL-201 (Neoleukin Therapeutics) NL-201 Phase 1 Clinical Neoleukin Therapeutics Inc Solid tumours Details
Recombinant human interleukin 15(Beijing Kawin) Phase 1 Clinical Beijing Kawin Technology Share-Holding Co Ltd Solid tumours Details

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