Recombinant ROR1 & ROR2 Proteins

The extracellular domain of ROR1 is made of three distinct domains, an immunoglobulin-like (Ig) domain, a frizzled domain, and a kringle domain (Borcherding et al., 2014). Interestingly, antibodies targeting different domains demonstrate a marked difference in therapeutic efficacy when used to treat leukemia cell lines (Daneshmanesh et al., 2013).

ACROBiosystems provides a comprehensive panel of human ROR1 proteins, including product of each single domain (Ig-like, Frizzled, Kringle), and the entire ECD of all three domains. We also have pre-biotinylated ROR1 (ECD). These proteins are generated using Avitag technology. The biotin tag is precisely conjugated on the single Avitag introduced at the C-terminus of the protein. This site-specific labeling method has many advantages over the commonly used NHS-labeling. It not only 100% preserves the protein's natural structure, but also confers uniform labeling efficiency and bioactivity. These pre-labeled products have been used to screen for anti-ROR1 mAbs. Moreover, we also developed mouse and rat ROR1 proteins for animal studies. (see full product list below)