Human TDP-43 Protein, His Tag

Customer Reviews
Cat. No. / Size
Price
Qty
TD3-H5145-25ug
$145.00
TD3-H5145-100ug
$360.00
TD3-H5145-500ug
$1080.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    TAR DNA-binding protein 43

  • Source

    Human TDP-43, His Tag (TD3-H5145) is expressed from E. coli cells. It contains AA Met 1 - Met 414 (Accession # Q13148-1).

    Predicted N-terminus: Met

    Request for sequence
  • Molecular Characterization

    TDP-43 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 46.8 kDa. The protein migrates as 54-56 kDa under reducing (R) condition (SDS-PAGE).

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Supplied as 0.2 μm filtered solution in 50 mM HEPES, 500 mM NaCl, 0.4 M Arginine, pH8.0 with glycerol as protectant.

    Contact us for customized product form or formulation.

  • Shipping and Storage

    This product is supplied and shipped on dry ice.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 12 months under sterile conditions.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    TDP-43 SDS-PAGE

    Human TDP-43, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

  • Bioactivity-ELISA

     TDP-43 ELISA

    Immobilized Human TDP-43, His Tag (Cat. No. TD3-H5145) at 1 μg/mL (100 μL/well) can bind Anti-TDP43 Antibody with a linear range of 0.2-3 ng/mL (QC tested).

    Protocol

Customer Reviews
Writing Reviews

  • n***l2026-04-14
    Likes
    We ordered Human TDP-43 Protein, His Tag and was very happy with the fast shipping to get our project going. Customer service was very helpful on the phone before I placed my order online.

Background

TDP-43, the transactive response (TAR)-DNA binding Protein with a molecular weight of 43 KDa is encoded by TARDBP gene that located at the chromosome 1. It is a RNA/DNA binding protein that structurally resembles a typical hnRNP protein family member. involved in transcriptional regulation and RNA processing. It is linked to sporadic and familial amyotrophic lateral sclerosis and frontotemporal lobar degeneration. TDP-43 is predominantly nuclear, but it translocates to the cytoplasm under pathological conditions. Cytoplasmic accumulation, phosphorylation, ubiquitination and truncation of TDP-43 are the main hallmarks of TDP-43 proteinopathies.

Recent Advances

 
Drug Development Progress
  • English Name:

    TAR DNA binding protein 43

  • Category:

  • Approved Drugs:

    0 Details

  • Drugs in Clinical Trials:

    6 Details

  • Highest Development Stage:

    Phase 3 Clinical

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