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Mesothelin

Mesothelin

Mesothelin Overview

Molecule Name
Mesothelin
Synonyms
MSLN,Mesothelin,MPF
Drug Development Progress
Drugs in Clinical Trials59
Approved Drugs0
Highest Development StagePhase 2 Clinical
Target Synonym
Pre-pro-megakaryocyte-potentiating factor，Mesothelin，MSLN，CAK1 Antigen，MPF，Soluble MPF Mesothelin Related Protein，Megakaryocyte Potentiating Factor，SMRP，CAK1
Background
Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.

Mesothelin Product List

Species
  • Human（24）
  • Mouse（3）
  • Cynomolgus（2）
  • Rat（1）
Tag
  • His Tag（17）
  • Fc Tag（7）
  • His Tag & Avi Tag（5）
  • Fc Tag & Avi Tag（1）
Host
  • HEK293（30）
Conjugate
  • Unconjugated（10）
  • Biotin-labeled（8）
  • FITC Labeled（4）
  • APC Labeled（2）
  • PE Labeled（2）
  • AF488 Labeled（1）
  • AF555 Labeled（1）
  • AF647 Labeled（1）
  • GFP Fusion（1）
Grade
  • RUO（26）
  • PG (pre-GMP)（4）
Low Endotoxin
  • No（30）
MoleculeCat. No.Product NameSpeciesHostStructurePurityActivitySize&Price
Mesothelin
HOTAvitag
MSN-H82E7
Biotinylated Human Mesothelin / MSLN (296-600) Protein, His,Avitag™ (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISA

$360.00

25ug
Mesothelin
HOTAIDD‑Ready
MSN-H522a
Human Mesothelin / MSLN (296-580) Protein, His Tag, premium grade
Human
HEK293
MALSSDS-PAGE
ELISABLIFlow

$475.00

100ug
Mesothelin
HOTDMF
MSN-HP2H5
PE-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag (Site-specific conjugation)
Human
HEK293
Flow

$415.00

25tests
Mesothelin
HOTAvitagDMF
MSN-H82E9
Biotinylated Human Mesothelin / MSLN (296-580) Protein, His,Avitag™, premium grade
Human
HEK293
MALSSDS-PAGE
ELISAFlow

$280.00

25ug
Mesothelin
HOT
MSN-HP2H8
PE-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
Human
HEK293
Flow

$415.00

25tests
Mesothelin
AIDD‑Ready
MSN-C52H6
Cynomolgus Mesothelin / MSLN (296-580) Protein, His Tag (MALS verified)
Cynomolgus
HEK293
MALSSDS-PAGE
ELISABLI

$360.00

100ug
Mesothelin
Avitag
MSN-C82E3
Biotinylated Cynomolgus Mesothelin / MSLN Protein, His,Avitag™ (MALS verified)
Cynomolgus
HEK293
MALSSDS-PAGE
ELISA

$360.00

25ug
Mesothelin
MSN-H5222
Human Mesothelin / MSLN (37-286) Protein, His Tag (MALS verified)
Human
HEK293
MALSSDS-PAGE

$290.00

100ug
Mesothelin
MSN-H5253
Human Mesothelin / MSLN (296-580) Protein, Fc Tag, premium grade
Human
HEK293
MALSSDS-PAGE
ELISAFlow

$290.00

100ug
Mesothelin
MSN-H5267
Human Mesothelin / MSLN (391-598) Protein, Fc Tag (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISA

$455.00

100ug
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Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
RC-88RC-88Phase 2 Clinical
Carcinoma, Ovarian Epithelial; Fallopian Tube Neoplasms; Neoplasms; Peritoneal Neoplasms; Solid tumours
Details
iCasp9M28ziCasp9M28zPhase 2 ClinicalMemorial Sloan Kettering Cancer Center
Breast Neoplasms; Lung Neoplasms; Mesothelioma; Neoplasm Metastasis; Pleural Diseases
Details
Anetumab ravtansineBAY-94-9343; BAY-94-9343-SPDB-DM4; Anti-mesothelin antibody-drug conjugate BAY 94-9343Phase 2 ClinicalBayer AG, Morphosys Ag
Carcinoma, Endometrioid; Fallopian Tube Neoplasms; Lung Neoplasms; Mesothelioma; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Solid tumours
Details
Gavocabtagene autoleucelTC-210Phase 2 ClinicalTcr2 Therapeutics Inc
Carcinoma, Non-Small-Cell Lung; Cholangiocarcinoma; Mesothelioma; Ovarian Neoplasms
Details
LMB-100LMB-100; RG-7787; RO-6927005Phase 2 ClinicalF. Hoffmann-La Roche Ltd
Adenocarcinoma of Lung; Carcinoma; Carcinoma, Non-Small-Cell Lung; Cholangiocarcinoma; Lung Neoplasms; Mesothelioma; Neoplasms; Neoplasms, Mesothelial; Pancreatic Neoplasms; Pleural Effusion, Malignant
Details
Anti-CTLA-4 and PD-1 CAR-T cell therapy (Shanghai Cell Therapy Research Institute)Phase 2 ClinicalShanghai Cell Therapy Research Institute
Neoplasms
Details
EB-DNK101EB-DNK101Phase 2 ClinicalBeijing Biotech
Carcinoma, Pancreatic Ductal
Details
EB-NK-MM (MSLN/MUC16)EB-NK-MMPhase 2 ClinicalBeijing Biotech
Carcinoma, Ovarian Epithelial; Fallopian Tube Neoplasms; Peritoneal Neoplasms
Details
EB-NK-MF (MSLN/FRalpha)EB-NK-MFPhase 2 ClinicalBeijing Biotech
Carcinoma, Ovarian Epithelial; Fallopian Tube Neoplasms; Glioblastoma; Glioma; Peritoneal Neoplasms
Details
EB-DuoNK-MSLN/HER2 cell therapy (Beijing Biotech)Phase 2 ClinicalBeijing Biotech
Carcinoma, Non-Small-Cell Lung
Details
MSLN CAR-T cell therapy (Shenzhen University General Hospital)Phase 2 ClinicalShenzhen University General Hospital
Solid tumours
Details
A2B-543A2B543Phase 2 ClinicalA2 Biotherapeutics Inc
Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colonic Neoplasms; Colorectal Neoplasms; Lung Neoplasms; Mesothelioma; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Rectal Neoplasms; Solid tumours
Details
Mesothelin targeting CAR-T cell therapy (Essen Biotech)Phase 2 ClinicalEssen Biotech
Pancreatic Neoplasms
Details
HY-05350HY-0005; HY-05350Phase 2 ClinicalSichuan Huiyu Seacross Pharma Technology Ltd
Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Mesothelioma; Ovarian Neoplasms; Pancreatic Neoplasms; Solid tumours
Details
TCR-like CAR-T Cell Therapy(Zhongda Hospital Southeast University)Phase 2 ClinicalZhongda Hospital Southeast University
Ovarian Neoplasms
Details
CD40 ligand expressing MSLN-CAR T cellsPhase 2 ClinicalPla General Hospital
Solid tumours
Details
A2B-694A2B-694; A2B694Phase 2 ClinicalA2 Biotherapeutics Inc
Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colonic Neoplasms; Colorectal Neoplasms; Lung Neoplasms; Mesothelioma; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Rectal Neoplasms; Solid tumours
Details
RNA-Meso-CIR-TRNA-Meso-CIR-TPhase 1 ClinicalNovartis Pharma Ag, University Of Pennsylvania
Mesothelioma
Details
CART-mesoCART-mesoPhase 1 ClinicalNovartis Pharma Ag, University Of Pennsylvania
Adenocarcinoma of Lung; Breast Neoplasms; Carcinoma, Ovarian Epithelial; Carcinoma, Pancreatic Ductal; Fallopian Tube Neoplasms; Mesothelioma; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms
Details
anti-MESO CAR-T cells (Zhejiang University)UCLM802; UCLM-802Phase 1 ClinicalHrain Biotechnology Co Ltd, Zhejiang University
Ovarian Neoplasms; Solid tumours
Details
Anti-mesothelin thorium-227 labeled antibody chelator conjugateBAY-2287411Phase 1 ClinicalBayer AG
Carcinoma, Pancreatic Ductal; Mesothelioma; Ovarian Neoplasms
Details
huMesoCARTMSLN-12; MSLN-18; SS-1; MSLN-23; MSLN-11; MSLN-14; MSLN-16; MSLN-21; MSLN-5Phase 1 ClinicalUniversity Of Pennsylvania
Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Fallopian Tube Neoplasms; Mesothelioma; Metastatic breast cancer; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms
Details
PSMA/NKG2DL/FAP-targeted Hi-TCR-T cellsPhase 1 ClinicalShenzhen Misheng Biotechnology Co Ltd
Prostatic Neoplasms; Solid tumours
Details
GC-503GC-503Phase 1 ClinicalGracell Biotechnologies Inc
Solid tumours
Details
iCasp9M28z T cellsPhase 1 ClinicalMemorial Sloan Kettering Cancer Center
Breast Neoplasms; Lung Neoplasms; Mesothelioma
Details
anti-mesothelin CAR T-cell therapy (Chinese PLA General Hospital)Phase 1 ClinicalPla General Hospital
Solid tumours
Details
HPN-536HPN-536Phase 1 ClinicalHarpoon Therapeutics
Neoplasms
Details
AB-1015AB-1015Phase 1 ClinicalArsenal Biosciences Inc
Carcinoma, Ovarian Epithelial; Ovarian Neoplasms
Details
SynKIR-110SynKIR™-110; SynKIR-mesoPhase 1 ClinicalVerismo Therapeutics Inc
Cholangiocarcinoma; Mesothelioma; Ovarian Neoplasms
Details
KT-032KT-032Phase 1 ClinicalNanjing Kati Medical Technology Co Ltd
Mesothelioma; Ovarian Neoplasms; Pancreatic Neoplasms; Solid tumours
Details
NI-1801NI-1801Phase 1 ClinicalLight Chain Bioscience Ltd
Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Pancreatic Ductal; Solid tumours; Triple Negative Breast Neoplasms
Details
UCLM-805UCLM-805; UCLM805Phase 1 ClinicalUTC Therapeutics Inc
Solid tumours
Details
FC-004FC004; FC-004Phase 1 ClinicalCancer Center Of Sun Yat Sen University
Ovarian Neoplasms
Details
MSLN-CAR T cells(Yihao Biotech)SHYH006; SHYH-006Phase 1 ClinicalShanghai Yihao Biotechnology Co Ltd
Ovarian Neoplasms
Details
Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells therapy(NIH)TNhYP218; TNhYP217; TNhYP-218; TNhYP-217Phase 1 ClinicalNational Cancer Institute
Colonic Neoplasms; Lung Neoplasms; Mesothelioma; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Stomach Neoplasms; Thymus Neoplasms
Details
Mesothelin x CD3 Bispecific Antibody(Integral Molecular)CT-95; LNK101; LNK-101Phase 1 ClinicalIntegral Molecular Inc
Carcinoma, Ovarian Epithelial; Cholangiocarcinoma; Colorectal Neoplasms; Mesothelioma; Neoplasm Metastasis; Neoplasms; Pancreatic Neoplasms; Solid tumours
Details
BZT-2312BZT-2312Phase 1 ClinicalShanghai Cell Therapy Group Co Ltd
Solid tumours
Details
JNJ-79032421JNJ-79032421; JNJ-2421Phase 1 ClinicalJanssen Research & Development Llc
Solid tumours
Details
YL-215YL215; YL-215Phase 1 ClinicalMediLink Therapeutics Co Ltd
Solid tumours
Details
GPC3/Mesothelin-CAR-γδT Cells therapy(Second Affiliated Hospital Of Guangzhou Medical University)Phase 1 ClinicalSecond Affiliated Hospital Of Guangzhou Medical University
Liver Neoplasms; Lung Neoplasms; Mesothelioma; Pancreatic Neoplasms; Solid tumours
Details
OPB-101OPB-101Phase 1 ClinicalOutpace Bio Inc
Ovarian Diseases; Ovarian Neoplasms
Details
AMG 305AMG 305; AMG-305Phase 1 ClinicalAmgen Inc
Solid tumours
Details
Mesothelin-CAR-T Cells (Fapon Biopharma)Phase 1 ClinicalGuangdong Fapon Biopharma Inc
Pancreatic Neoplasms
Details
UCMYM-802UCMYM802; UCMYM-802Phase 1 ClinicalUTC Therapeutics Inc
Bile Duct Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Mesothelioma; Ovarian Neoplasms; Pancreatic Neoplasms; Rectal Neoplasms; Solid tumours
Details
HBM-9033HBM9033; SGN-MesoC2; HBM-9033; PF-08052666Phase 1 ClinicalNona Biosciences
Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Endometrial Neoplasms; Mesothelioma; Ovarian Neoplasms; Pancreatic Neoplasms; Solid tumours
Details
LD-013LD013; LD-013Phase 1 ClinicalNanjing Blue Shield Biotech Co Ltd
Ovarian Neoplasms; Solid tumours
Details
Ori-C-613Ori-C-613; OriC-613; Ori-C613Phase 1 ClinicalOriCell Therapeutics Co Ltd
Solid tumours
Details
RD-138RD-138Phase 1 ClinicalNanjing Iaso Biotherapeutics Co Ltd
Multiple Myeloma
Details
RD-133RD133Phase 1 ClinicalNanjing Iaso Biotherapeutics Co Ltd
Neoplasms; Solid tumours
Details
PM-3006PM-3006Phase 1 Clinical
Details
Anti-mesothelin CAR-NK cell therapy(Guojianchengnuo)ALF-101Phase 1 ClinicalGuojianchengnuo Biotechnology (Beijing) Co Ltd
Carcinoma, Ovarian Epithelial
Details
InezetamabAMG-994Phase 1 ClinicalAmgen Inc
Solid tumours
Details
ATA-2271ATA-2271Phase 1 ClinicalAtara Biotherapeutics Inc, Bayer AG, Memorial Sloan Kettering Cancer Center
Adenocarcinoma; Breast Neoplasms; Diabetes Mellitus; Esophageal adenocarcinoma; Esophageal Neoplasms; Mesothelioma; Neoplasms; Peritoneal Neoplasms; Stomach Neoplasms
Details
αPD1-MSLN-CAR T cell therapy (Shanghai Cell Therapy Group Co.,Ltd)BZDS1901; BZDS-1901; BZD1901Phase 1 ClinicalShanghai Cell Therapy Group Co Ltd
Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Mesothelioma; Ovarian Neoplasms; Solid tumours
Details
KD-021KD-021Phase 1 ClinicalNanjing Kaidi Medical Technology Co Ltd
Neoplasms
Details
anti-mesothelin CAR T-cell therapy (Shenzhen BinDeBio)ClinicalShenzhen Bindebio Ltd
Pancreatic Neoplasms
Details
Universal Chimeric Antigen Receptor T-Cell Immunotherapy(Calmhome Cell and Gene Engineering Institute)CHT-102; CHT102ClinicalNanjing Calmhome Cell and Gene Engineering Institute Co Ltd, Tianjin Medical University Cancer Institute And Hospital
Pancreatic Neoplasms; Solid tumours
Details
Anti-mesothelin CAR T cell therapy (UTC Therapeutics Inc)ClinicalUTC Therapeutics Inc
Solid tumours
Details
Anti-mesothelin CAR-T (Pregene)ClinicalPregene (Shenzhen) Biotechnology Co Ltd
Hydrothorax
Details
Customer Reviews
  • B***a2023-07-11
    APC-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
    This is one of the only conjugated mesothelin proteins available on the market! It has great specificity for flow cytometry staining, this has been a game changer for us to measure human mesothelin present in our samples with an easy and quick one-step staining method. This is a great quality product and we will be ordering so many more in the future!