언어 선택

NOTCH1

NOTCH1 분자 정보

영어 이름	Neurogenic locus notch homolog protein 1	시판 약물 수	0
임상 약물 수	1	표적 별명	Notch Receptor 1，EC 2.1.2.11，Translocation-associated notch protein TAN-1，NEXT，NICD，hN1，NOTCH1，Notch 1，TAN1，Notch (Drosophila) Homolog 1 (Translocation-Associated)，Notch Homolog 1， Translocation-Associated (Drosophila)，Notch Homolog 1， Translocation-Associated，AOVD1，AOS5，Receptor， Notch1，EC 3.4.21.68，Neurogenic locus notch homolog protein 1
최고 연구 개발 단계	Phase 1 Clinical

영어 이름	Neurogenic locus notch homolog protein 1
표적 별명	Notch Receptor 1，EC 2.1.2.11，Translocation-associated notch protein TAN-1，NEXT，NICD，hN1，NOTCH1，Notch 1，TAN1，Notch (Drosophila) Homolog 1 (Translocation-Associated)，Notch Homolog 1， Translocation-Associated (Drosophila)，Notch Homolog 1， Translocation-Associated，AOVD1，AOS5，Receptor， Notch1，EC 3.4.21.68，Neurogenic locus notch homolog protein 1
시판 약물 수	0
임상 약물 수	1
최고 연구 개발 단계	Phase 1 Clinical

NOTCH1 제품 목록

속성
Protein (4)
제품 라이브러리
온라인 (4)
종
Mouse (1)Human (3)
태그
His Tag (2)Fc Tag (2)
마커
Unconjugated (3)Biotin-labeled (1)

제품 번호	종	발현 시스템	제품 설명
HOT NO1-H52H3	Human	HEK293	Human NOTCH1 Protein, His Tag, premium grade
NO1-H5255	Human	HEK293	Human NOTCH1 Protein, Fc Tag (MALS verified)
NO1-H8253	Human	HEK293	Biotinylated Human NOTCH1 Protein, Fc Tag, ultra sensitivity (primary amine labeling)
NO1-M52H8	Mouse	HEK293	Mouse NOTCH1 Protein, His Tag

총 수량4

NOTCH1분자 배경

NOTCH1 Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1. The NOTCH1 intracellular domain interacts with SNW1; the interaction involves multimerized NOTCH1 NICD and is implicated in a formation of an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ. The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia.

NOTCH1분자 별명

NOTCH1,Notch 1,hN1,TAN1

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Crenigacestat	JSMD-194; LY-3039478; BMS-986405	Phase 1 Clinical	Eli Lilly And Company	Breast Neoplasms; Carcinoma, Adenoid Cystic; Carcinoma, Hepatocellular; Cholangiocarcinoma; Colonic Neoplasms; Leiomyosarcoma; Leukemia, B-Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, T-Cell; Lymphoma; Lymphoma, B-Cell; Lymphoma, T-Cell; Multiple Myeloma; Neoplasm Metastasis; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Sarcoma; Solid tumours; Triple Negative Breast Neoplasms	상세