Human MAOB / Monoamine Oxidase B Protein, His Tag (active enzyme)

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Cat. No. / Size
Price
Qty
MAB-H5547-20ug
$245.00
MAB-H5547-500ug
$2225.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    MAOB, MAO-B, Monoamine Oxidase B, Monoamine oxidase type B

  • Source

    Human MAOB, His Tag (MAB-H5547) is expressed from Baculovirus-Insect cells. It contains AA Ser 2 - Val 520 (Accession # P27338-1).

    Predicted N-terminus: Met

    Request for sequence
  • Molecular Characterization

    Monoamine oxidase B Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 60.6 kDa. The protein migrates as 55 kDa under reducing (R) condition (SDS-PAGE).

    *The DDM/CHS buffer (Cat. No. DC-11) is sold separately and not included in protein, you can follow the link for product information.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    This product is not suitable for cell based experiments due to cytotoxicity of DDM.
    DDM and CHS are INDISPENSABLE to keep membrane protein soluble and active, under no circumstances should you remove DDM and CHS.
    DDM/CHS buffer (DC-11) is sold separately and not included in protein, and please contact us if you need the buffer.
    If glycerol is not compatible with your application, remove glycerol just before the immediate experiment, and NEVER store glycerol-free protein solution.

    Supplied as 0.2 μm filtered solution in 50 mM HEPES, 150 mM NaCl, DDM, CHS, pH7.5 with glycerol as protectant.

    Contact us for customized product form or formulation.

  • Shipping and Storage

    This product is supplied and shipped on dry ice.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    Monoamine oxidase B SDS-PAGE

    Human MAOB, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

  • Bioactivity

    Measured by its ability to produce hydrogen peroxide during the oxidation of benzylamine. The specific activity is >35 pmol/min/μg (QC tested).

    Protocol

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Background

Monoamine Oxidase Type B (MAOB) is an enzyme located in the outer mitochondrial membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the breakdown of dopamine in the brain. MAOB inhibitors, that reduces dopamine turnover, are in clinical use for the treatment of Parkinson's disease (PD).

Recent Advances

 
Drug Development Progress
  • English Name:

    Monoamine oxidase B

  • Category:

  • Approved Drugs:

    3 Details

  • Drugs in Clinical Trials:

    11 Details

  • Highest Development Stage:

    Approved

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