Human IL-2 R beta / CD122 Protein, Fc Tag (MALS & SPR verified)

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제품 번호/규격
가격
수량
ILB-H5253-50ug
$360.00
ILB-H5253-1mg (500ug X 2)
$2780.00
ETA of in-stock products:2 business days
총 항목 수 제품 금액$ 0

제품 세부정보

  • Synonyms

    IL2RB, RP5-1170K4.6, CD122, P70-75

  • Source

    Human IL-2 R beta, Fc Tag (ILB-H5253) is expressed from human 293 cells (HEK293). It contains AA Ala 27 - Asp 239 (Accession # P14784-1).

    Predicted N-terminus: Ala 27

    Request for sequence
  • Molecular Characterization

    IL-2 R beta Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 51.0 kDa. The protein migrates as 60-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

고객님도 확인한 상품

데이터 표시

  • SDS-PAGE

    IL-2 R beta SDS-PAGE

    Human IL-2 R beta, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    IL-2 R beta SEC-MALS

    The purity of Human IL-2 R beta, Fc Tag (Cat. No. ILB-H5253) is more than 85% and the molecular weight of this protein is around 110-135 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     IL-2 R beta ELISA

    Immobilized Human IL-15, premium grade (Cat. No. IL5-H4117) at 5 μg/mL (100 μL/well) can bind Human IL-2 R beta, Fc Tag (Cat. No. ILB-H5253) with a linear range of 5-156 ng/mL (Routinely tested).

    Protocol
  • Bioactivity-SPR

     IL-2 R beta SPR

    Human IL-2 R beta, Fc Tag (Cat. No. ILB-H5253) captured on CM5 chip via anti-human IgG Fc antibody can bind IL-2, Tag Free with an affinity constant of 0.473 μM as determined in a SPR assay (Biacore T200) (QC tested).

    Protocol

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배경 소개

Interleukin-2 receptor (IL-2R) is a heterotrimeric protein expressed on the surface of certain immune cells, such as lymphocytes, that binds and responds to a cytokine called IL-2. The IL-2R is made up of 3 subunits - α (CD25), β (CD122) and γ (CD132) - non-covalently associating. The α and β chains are involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the γ-chain, along with the β subunit.
CD122 is also known as IL2R beta, is a member of the type I cytokine receptor family. CD122 is the receptor for interleukin-2 and is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.

프론티어 진행

 
의약품 개발 진행
  • 영어 이름:

    Interleukin-2 receptor beta chain

  • 카테고리:

  • 상장 의약품 수:

    0 상세

  • 임상 의약품 수:

    15 상세

  • 최고 개발 단계:

    Phase 3 Clinical

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