Biotinylated Human CNTF R alpha Protein, His,Avitag™

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Cat. No. / Size
Price
Qty
CNR-H82Q3-25ug
$405.00
CNR-H82Q3-200ug
$1645.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    CNTFR, CNTF R alpha

  • Source

    Biotinylated Human CNTF R alpha Protein, His,Avitag (CNR-H82Q3) is expressed from human 293 cells (HEK293). It contains AA Gln 23 - Pro 346 (Accession # P26992).

    Predicted N-terminus: His

  • Molecular Characterization

    CNTF R alpha Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the N-terminus, followed by an Avi tag (Avitag™).

    The protein has a calculated MW of 39.8 kDa. The protein migrates as 53-63 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Labeling

    Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.

  • Protein Ratio

    Passed as determined by the HABA assay / binding ELISA.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    CNTF R alpha SDS-PAGE

    Biotinylated Human CNTF R alpha Protein, His,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

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Background

CNTF receptor alpha (CNTFR) is a specialized protein primarily expressed in the nervous system and skeletal muscle. Unlike many receptors, it lacks a transmembrane domain and anchors to the cell surface via a GPI linkage. It functions as a crucial signaling component that binds Ciliary Neurotrophic Factor, subsequently recruiting gp130 and LIFR to initiate the JAK/STAT pathway. This process is vital for promoting neuronal survival, guiding motor neuron development, and regulating muscle regeneration.

Recent Advances

 
Drug Development Progress
  • English Name:

    Ciliary neurotrophic factor receptor

  • Category:

  • Approved Drugs:

    1 Details

  • Drugs in Clinical Trials:

    0 Details

  • Highest Development Stage:

    Approved

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