Biotinylated Human TACI / TNFRSF13B Protein, His,Avitag™ (MALS verified)

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제품 번호/규격
가격
수량
TAI-H82E3-25ug
$360.00
TAI-H82E3-200ug
$1565.00
ETA of in-stock products:2 business days
총 항목 수 제품 금액$ 0

제품 세부정보

  • Synonyms

    CD267, TACI, TNFRSF13B

  • Source

    Biotinylated Human TACI Protein, His,Avitag (TAI-H82E3) is expressed from human 293 cells (HEK293). It contains AA Ser 2 - Thr 166 (Accession # O14836-1).

    Request for sequence
  • Molecular Characterization

    TACI Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™).

    The protein has a calculated MW of 22.2 kDa. The protein migrates as 22-25 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Labeling

    Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.

  • Protein Ratio

    Passed as determined by the HABA assay / binding ELISA.

  • Purity

    >90% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, 0.2 M Arginine, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

고객님도 확인한 상품

데이터 표시

  • SDS-PAGE

    TACI SDS-PAGE

    Biotinylated Human TACI Protein, His,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    TACI SEC-MALS

    The purity of Biotinylated Human TACI Protein, His,Avitag (Cat. No. TAI-H82E3) is more than 95% and the molecular weight of this protein is around 22-30 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     TACI ELISA

    Immobilized Human BAFF Protein, Fc Tag (Cat. No. BAF-H5261) at 1 μg/mL (100 μL/well) can bind Biotinylated Human TACI Protein, His,Avitag (Cat. No. TAI-H82E3) with a linear range of 0.02-1 ng/mL (QC tested).

    Protocol
  •  TACI ELISA

    Immobilized Biotinylated Human TACI Protein, His,Avitag (Cat. No. TAI-H82E3) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Human APRIL Protein, Fc Tag (Cat. No. APL-H5363) with a linear range of 0.02-6 ng/mL (Routinely tested).

    Protocol

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배경 소개

Transmembrane activator and CAML interactor (TACI), also known as tumor necrosis factor receptor superfamily member 13B (TNFRSF13B). It was originally discovered because of its ability to interact with calcium-modulator and cyclophilin ligand (CAML). TACI was later found to play a crucial role in humoral immunity by interacting with two members of the TNF family: BAFF and APRIL.
The present study demonstrated that, in NSCLC, a proliferation-inducing ligand (APRIL), B-cell maturation antigen (BCMA)and transmembrane activator and CAML interactor (TACI) proteins are abnormally expressed by immunohistochemistry, reverse transcription-quantitative polymerase chain reaction and western blotting. In addition, the expression of APRIL, BCMA and TACI were observed to be involved in extracellular signal-regulated kinase (ERK)1/2 activation in A549 cells.

프론티어 진행

 
의약품 개발 진행
  • 영어 이름:

    Tumor necrosis factor receptor superfamily member 13B

  • 카테고리:

  • 상장 의약품 수:

    0 상세

  • 임상 의약품 수:

    0 상세

  • 최고 개발 단계:

    Preclinical

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