Cynomolgus SIRP alpha / CD172a Protein, Fc Tag (MALS verified)

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제품 번호/규격
가격
수량
SIA-C5254-100ug
$310.00
SIA-C5254-1mg (500ug X 2)
$2245.00
ETA of in-stock products:2 business days
총 항목 수 제품 금액$ 0

제품 세부정보

  • Synonyms

    SHPS1, SIRPA, CD172A, BIT, MFR, MYD1, P84, PTPNS1

  • Source

    Cynomolgus SIRP alpha, Fc Tag (SIA-C5254) is expressed from human 293 cells (HEK293). It contains AA Glu 31 - Asn 370 (Accession # NP_001271679.1).

    Predicted N-terminus: Glu31

    Request for sequence
  • Molecular Characterization

    SIRP alpha Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 63.6 kDa. The protein migrates as 70-85 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

고객님도 확인한 상품

데이터 표시

  • SDS-PAGE

    SIRP alpha SDS-PAGE

    Cynomolgus SIRP alpha, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • SEC-MALS

    SIRP alpha SEC-MALS

    The purity of Cynomolgus SIRP alpha, Fc Tag (Cat. No. SIA-C5254) is more than 90% and the molecular weight of this protein is around 150-180 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     SIRP alpha ELISA

    Immobilized Cynomolgus / Rhesus macaque CD47, His Tag (Cat. No. CD7-C52H1) at 2 μg/mL (100 μL/well) can bind Cynomolgus SIRP alpha, Fc Tag (Cat. No. SIA-C5254) with a linear range of 0.01-0.3 μg/mL (QC tested).

    Protocol

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배경 소개

Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

프론티어 진행

 
의약품 개발 진행
  • 영어 이름:

    Signal-regulatory protein alpha

  • 카테고리:

  • 상장 의약품 수:

    2 상세

  • 임상 의약품 수:

    19 상세

  • 최고 개발 단계:

    Approved

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  • 배경
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