Cynomolgus NKp46 / NCR1 / CD335 Protein, Llama IgG2b Fc Tag, low endotoxin

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제품 번호/규격
가격
수량
NC1-C5255-100ug
$395.00
NC1-C5255-1mg (500ug X 2)
$2615.00
ETA of in-stock products:2 business days
총 항목 수 제품 금액$ 0

제품 세부정보

  • Synonyms

    NCR1, LY94, CD335, NK-p46, hNKp46

  • Source

    Cynomolgus NKp46, Llama IgG2b Fc Tag (NC1-C5255) is expressed from human 293 cells (HEK293). It contains AA Pro 22 - Arg 257 (Accession # Q95JB9-1).

    Request for sequence
  • Molecular Characterization

    NKp46 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a llama IgG2b Fc tag at the C-terminus.

    The protein has a calculated MW of 54.7 kDa. The protein migrates as 60-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    After reconstitution, this product is stable after storage at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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데이터 표시

  • SDS-PAGE

    NKp46 SDS-PAGE

    Cynomolgus NKp46, Llama IgG2b Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

  • Bioactivity-ELISA

     NKp46 ELISA

    Immobilized Cynomolgus NKp46, Llama IgG2b Fc Tag (Cat. No. NC1-C5255) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-NKp46 Antibody, Human IgG1 with a linear range of 0.1-4 ng/mL (QC tested).

    Protocol

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배경 소개

Natural cytotoxicity triggering receptor 1 (NCR1) is also known as Natural killer cell p46-related protein (NK-p46), Lymphocyte antigen 94 homolog (LY94), CD antigen CD335, which belongs to the natural cytotoxicity receptor (NCR) family. NCR1 contains two Ig-like (immunoglobulin-like) domains. NCR1 interacts with CD247 and FCER1G. NCR1 / CD335 may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

프론티어 진행

 
의약품 개발 진행
  • 영어 이름:

    Natural cytotoxicity triggering receptor 1

  • 카테고리:

  • 상장 의약품 수:

    0 상세

  • 임상 의약품 수:

    3 상세

  • 최고 개발 단계:

    Phase 2 Clinical

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