Human IL-31 RA Protein, His Tag, low endotoxin (MALS & SPR verified)

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제품 번호/규격
가격
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ILA-H52H7-100ug
$435.00
ILA-H52H7-1mg (500ug X 2)
$2745.00
ETA of in-stock products:2 business days
총 항목 수 제품 금액$ 0

제품 세부정보

  • Synonyms

    IL-31 RA, IL-31RA, hGLM-R, CRL3, GPL, ZcytoR17, GLM-R, IL-31R-alpha, Gp130-like receptor

  • Source

    Human IL-31 RA, His Tag (ILA-H52H7) is expressed from human 293 cells (HEK293). It contains AA Ala 20 - Glu 519 (Accession # Q8NI17-1).

    Predicted N-terminus: Ala 20

    Request for sequence
  • Molecular Characterization

    IL-31 RA Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 59.0 kDa. The protein migrates as 90-110 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

고객님도 확인한 상품

데이터 표시

  • SDS-PAGE

    IL-31 RA SDS-PAGE

    Human IL-31 RA, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    IL-31 RA SEC-MALS

    The purity of Human IL-31 RA, His Tag (Cat. No. ILA-H52H7) is more than 95% and the molecular weight of this protein is around 80-110 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     IL-31 RA ELISA

    Immobilized Nemolizumab at 5 μg/mL (100 μL/well) can bind Human IL-31 RA, His Tag (Cat. No. ILA-H52H7) with a linear range of 1-39 ng/mL (Routinely tested).

    Protocol
  • Bioactivity-SPR

     IL-31 RA SPR

    Human IL-31, His Tag (Cat. No. IL1-H5247) immobilized on CM5 Chip can bind Human IL-31 RA, His Tag (Cat. No. ILA-H52H7) with an affinity constant of 52.1 nM as determined in a SPR assay (Biacore 8K) (QC tested).

    Protocol

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배경 소개

Interleukin-31 receptor subunit alpha is a protein that in humans is encoded by the IL31RA gene, also known as IL-31 receptor subunit alpha, IL-31RA, GLM-R, Gp130-like receptor, CRL3, GPL. Oncostatin M receptor (OSMR) and IL31RA form the heterodimeric receptor through which IL31 signals. IL31RA is a strong activator of STAT3 and STAT5, whereas STAT1 is only marginally tyrosine-phosphorylated. dditionally, demonstrate Jak1 binding to GPL and its activation in heteromeric complexes with the OSMRbeta but also in a homomeric receptor complex.

프론티어 진행

 
의약품 개발 진행
  • 영어 이름:

    Interleukin-31 receptor subunit alpha

  • 카테고리:

  • 상장 의약품 수:

    1 상세

  • 임상 의약품 수:

    0 상세

  • 최고 개발 단계:

    Approved

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