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Product Details
Synonyms
IL2RG, CD132, CIDX, IMD4, P64, SCIDX, SCIDX1, gammaC
Source
Human IL-2 R gamma, His Tag (ILA-H52H5) is expressed from human 293 cells (HEK293). It contains AA Leu 23 - Asn 254 (Accession # P31785-1).
Predicted N-terminus: Leu 23
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 29.3 kDa. The protein migrates as 55-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 0.01 EU per μg by the LAL method / rFC method.
Purity
>95% as determined by SDS-PAGE.
Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
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Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
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Performance Data
SDS-PAGE
Human IL-2 R gamma, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).
SEC-MALS
The purity of Human IL-2 R gamma, His Tag (Cat. No. ILA-H52H5) is more than 85% and the molecular weight of this protein is around 50-60 kDa verified by SEC-MALS.
Report
Bioactivity-ELISA
Immobilized Human IL-2 Protein, Fc Tag (Cat. No. IL2-H5269) at 5 μg/mL (100 μL/well), add 50 μl/well of Human IL-2 R gamma, His Tag (Cat. No. ILA-H52H5) at increasing concentrations and then add Human IL-2 R beta, Fc Tag (Cat. No. ILB-H5253) at 5 μg/mL (50 μL/well). Detection was performed using HRP conjugated Anti-His Antibody (AY63), mAb (Acro, Cat. No. HIS-PLM535) with sensitivity of 0.32 μg/mL (QC tested).
Protocol
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Background
Interleukin-2 receptor subunit gamma (IL2RG), also known as cytokine receptor common subunit gamma, CD antigen CD132, gammaC, p64, which belongs to the type I cytokine receptor family or type 5 subfamily. IL2RG is located on the surface of immature blood-forming cells in bone marrow. Defects in IL2RG are the cause of severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell-negative (XSCID).
Recent Advances
Drug Development Progress- English Name：
Interleukin-2 receptor subunit gamma
- Category：
- Approved Drugs：
0 Details
- Drugs in Clinical Trials：
14 Details
- Highest Development Stage：
Phase 2 Clinical
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