PE-Labeled Human IL-15 R alpha / CD215 Protein, Fc Tag (Site-specific conjugation)

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Cat. No. / Size
Price
Qty
ILA-HP2F6-25tests
$450.00
ILA-HP2F6-200tests
$2780.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    IL-15 R alpha, CD215, IL15RA, IL-15RA, IL-15R-alpha

  • Source

    PE-Labeled Human IL-15 R alpha / CD215 Protein, Fc Tag (Cat. No.ILA-HP2F6) is produced via site-specific conjugation of PE to Human IL-15 R alpha Protein, Fc Tag under optimal conditions with a proprietary technology. Human IL-15 R alpha, Fc Tag is expressed from human 293 cells (HEK293). It contains AA Ile 31 - Thr 205 (Accession # Q13261-1).

    Predicted N-terminus: Ile 31

    Request for sequence

  • Molecular Characterization

    IL-15 R alpha Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 46.6 kDa.

  • Conjugate

    PE

    Excitation Wavelength: 488 nm / 561 nm

    Emission Wavelength: 575 nm

  • Application

    Please note that this product is NOT compatible to streptavidin detection system.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, 0.5% BSA, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • Bioactivity-ELISA

     IL-15 R alpha ELISA

    Immobilized Human IL-15, His Tag (Cat. No. IL5-H52H8) at 2 μg/mL (100 μL/well) can bind PE-Labeled Human IL-15 R alpha, Fc Tag (Cat. No. ILA-HP2F6) with a linear range of 0.5-16 ng/mL (QC tested).

    Protocol

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Background

IL15R is a heterotrimer of IL15RA, IL2RB and IL2RG. IL-15RA, also known as CD215, IL-15 R alpha, is a widely expressed 60 kDa transmembrane glycoprotein. High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. An interleukin (IL)-15 superagonist/IL-15 receptor α fusion complex (IL-15SA/IL-15RA; ALT-803) activates the IL-15 receptor on CD8 T cells and NK cells, and has shown significant anti-tumor. Signal transduction involves SYK. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures.

Recent Advances

 
Drug Development Progress
  • English Name:

    Interleukin-15 receptor subunit alpha

  • Category:

  • Approved Drugs:

    0 Details

  • Drugs in Clinical Trials:

    13 Details

  • Highest Development Stage:

    Phase 3 Clinical

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