Cynomolgus GUCY2C / Guanylyl cyclase C Protein, His Tag, low endotoxin (MALS verified)

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제품 번호/규격
가격
수량
GUC-C52H6-100ug
$360.00
GUC-C52H6-1mg
$2615.00
ETA of in-stock products:2 business days
총 항목 수 제품 금액$ 0

제품 세부정보

  • Synonyms

    GUCY2C, GUC2C, STAR, STA receptor, hSTAR, GC-C

  • Source

    Cynomolgus GUCY2C, His Tag (GUC-C52H6) is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Gln 430 (Accession # XP_005570270.1).

    Predicted N-terminus: Ser 24

    Request for sequence
  • Molecular Characterization

    GUCY2C Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 48.0 kDa. The protein migrates as 65-95 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

고객님도 확인한 상품

데이터 표시

  • SDS-PAGE

    GUCY2C SDS-PAGE

    Cynomolgus GUCY2C, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    GUCY2C SEC-MALS

    The purity of Cynomolgus GUCY2C, His Tag (Cat. No. GUC-C52H6) is more than 95% and the molecular weight of this protein is around 60-80 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     GUCY2C ELISA

    Immobilized Cynomolgus GUCY2C, His Tag (Cat. No. GUC-C52H6) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Human GUCY2C Antibody, Human IgG1 with a linear range of 0.3-6 ng/mL (QC tested).

    Protocol
  •  GUCY2C ELISA

    Immobilized Monoclonal Anti-Human GUCY2C Antibody, Human IgG1 at 1 μg/mL (100 μL/well) can bind Cynomolgus GUCY2C, His Tag (Cat. No. GUC-C52H6) with a linear range of 3-25 ng/mL (Routinely tested).

    Protocol

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배경 소개

GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer.

프론티어 진행

 
의약품 개발 진행
  • 영어 이름:

    Heat-stable enterotoxin receptor

  • 카테고리:

  • 상장 의약품 수:

    1 상세

  • 임상 의약품 수:

    10 상세

  • 최고 개발 단계:

    Approved

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  • 고객님도 확인한 상품
  • 데이터 표시
  • 사용자 리뷰
  • 배경
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