Human GCGR / Glucagon receptor Protein, Fc Tag, low Endotoxin (MALS verified)

사용자 리뷰
제품 번호/규격
가격
수량
GCR-H53H3-50ug
$360.00
GCR-H53H3-1mg
$2885.00
ETA of in-stock products:2 business days
총 항목 수 제품 금액$ 0

제품 세부정보

  • Synonyms

    Glucagon R, GCGR, Glucagon receptor

  • Source

    Human GCGR Protein, Fc Tag (GCR-H53H3) is expressed from CHO cells. It contains AA Ala 26 - Lys 136 (Accession # P47871-1).

    Predicted N-terminus: Ala 26

    Request for sequence
  • Molecular Characterization

    GCGR Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 39.5 kDa. The protein migrates as 52-62 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

고객님도 확인한 상품

데이터 표시

  • SDS-PAGE

    GCGR SDS-PAGE

    Human GCGR Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • SEC-MALS

    GCGR SEC-MALS

    The purity of Human GCGR Protein, Fc Tag (Cat. No. GCR-H53H3) is more than 90% and the molecular weight of this protein is around 100-115 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     GCGR ELISA

    Immobilized Human GCGR Protein, Fc Tag (Cat. No. GCR-H53H3) at 1 μg/mL (100 μL/well) can bind Anti-GCGR Antibody,Human IgG4 with a linear range of 0.5-16 ng/mL (QC tested).

    Protocol
  •  GCGR ELISA

    Immobilized Human GCGR Protein, Fc Tag (Cat. No. GCR-H53H3) at 1 μg/mL (100 μL/well) can bind Anti-GCGR Antibody,Human IgG2 with a linear range of 0.2-16 ng/mL (Routinely tested).

    Protocol
  • Bioactivity-SPR

     GCGR SPR

    Human GCGR Protein, Fc Tag (Cat. No. GCR-H53H3) immobilized on CM5 Chip can bind GLP-1 (7-37) with an affinity constant of 51.1 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

    Protocol

사용자 리뷰
댓글 남기기

배경 소개

G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.

프론티어 진행

 
의약품 개발 진행
  • 영어 이름:

    Glucagon receptor

  • 카테고리:

  • 상장 의약품 수:

    6 상세

  • 임상 의약품 수:

    40 상세

  • 최고 개발 단계:

    Approved

연락하기
신약 후보물질 라이선싱
더 많이 알아보기
  • 기본 제품 정보
  • 제품 세부정보
  • 고객님도 확인한 상품
  • 데이터 표시
  • 사용자 리뷰
  • 배경
문의하기

전화
글로벌: +1 800-810-0816 (무료)
아시아태평양: +86 400-682-2521

주소 서울특별시 송파구 법원로11길 11, 제3층 제비-314,315호