Human DcR3 / TNFRSF6B Protein, His Tag, low endotoxin (MALS verified)

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제품 번호/규격
가격
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DC3-H52H3-50ug
$315.00
DC3-H52H3-1mg
$2500.00
ETA of in-stock products:2 business days
총 항목 수 제품 금액$ 0

제품 세부정보

  • Synonyms

    TNFRSF6B, DCR3, TR6, M68

  • Source

    Human DcR3 Protein, His Tag (DC3-H52H3) is expressed from human 293 cells (HEK293). It contains AA Val 30 - Ser 195 (Accession # O95407).

    Request for sequence
  • Molecular Characterization

    DcR3 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 20.1 kDa. The protein migrates as 27-33 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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데이터 표시

  • SDS-PAGE

    DcR3 SDS-PAGE

    Human DcR3 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    DcR3 SEC-MALS

    The purity of Human DcR3 Protein, His Tag (Cat. No. DC3-H52H3) is more than 85% and the molecular weight of this protein is around 22-32 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     DcR3 ELISA

    Immobilized Human DcR3 Protein, His Tag (Cat. No. DC3-H52H3) at 5 μg/mL (100 μL/well) can bind Biotinylated Human TL1A Protein, His,Avitag (Cat. No. TLA-H52Q1) with a linear range of 0.2-8 ng/mL (QC tested).

    Protocol
  •  DcR3 ELISA

    Immobilized Human TL1A Protein, Fc Tag at 5 μg/mL (100 μL/well) can bind Human DcR3 Protein, His Tag (Cat. No. DC3-H52H3) with a linear range of 1-31 ng/mL (Routinely tested).

    Protocol
  • Bioactivity-SPR

     DcR3 SPR

    Human TL1A Protein, Fc Tag (Cat. No. TLA-H5263) captured on Protein A Chip can bind Human DcR3 Protein, His Tag (Cat. No. DC3-H52H3) with an affinity constant of 21.7 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

    Protocol

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  • J***h2026-04-03
    좋아요
    Products always arrive very quickly. More quickly then nearly all other competitors, regardless of quantity ordered. We use Acro products as controls that our clients request. They have always been the most reliable in quantity and availability as opposed to BioTechne brands which sometimes take weeks for a quote to be processed, and then another month for delivery. Communication with Acro reps is quicker and more in depth then any of our 200 vendors.

배경 소개

Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B) is also known as Decoy Receptor 3 (DcR3), Decoy receptor for Fas ligand and M68, which belongs to the tumor necrosis factor receptor superfamily. TNFRSF6 is a soluble protein which contains four TNFR-Cys repeats. Unlike most of the other members of TNFR superfamily, TNFRSF6 is a soluble protein which contains no transmembrane domain. TNFRSF6B acts as a decoy receptor that competes with death receptors for ligand binding. The protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death and T cell activation as well as to induce angiogenesis via neutralization of TL1A.

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