Human CTLA-4 / CD152 Protein, Twin-Strep Tag

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제품 번호/규격
가격
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CT4-H5284-25ug
$270.00
CT4-H5284-250ug
$905.00
CT4-H5284-1mg (250ug X 4)
$2370.00
ETA of in-stock products:2 business days
총 항목 수 제품 금액$ 0

제품 세부정보

  • Synonyms

    CTLA4, CD152

  • Source

    Human CTLA-4 Protein, Twin-Strep Tag (CT4-H5284) is expressed from human 293 cells (HEK293). It contains AA Ala 37 - Phe 162 (Accession # P16410-1).

    Predicted N-terminus: Ala 37

    Request for sequence
  • Molecular Characterization

    CTLA-4 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a twin strep tag at the C-terminus.

    The protein has a calculated MW of 16.5 kDa. The protein migrates as 20-30 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >85% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

고객님도 확인한 상품

데이터 표시

  • SDS-PAGE

    CTLA-4 SDS-PAGE

    Human CTLA-4 Protein, Twin-Strep Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 85% (With Star Ribbon Pre-stained Protein Marker).

  • Bioactivity-ELISA

     CTLA-4 ELISA

    Immobilized Human B7-2, Fc Tag, premium grade (Cat. No. CD6-H5257) at 2 μg/mL (100 μL/well) can bind Human CTLA-4 Protein, Twin-Strep Tag (Cat. No. CT4-H5284) with a linear range of 1-20 ng/mL (QC tested).

    Protocol

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배경 소개

CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.

프론티어 진행

 
의약품 개발 진행
  • 영어 이름:

    Cytotoxic T-Lymphocyte-Associated Antigen 4

  • 카테고리:

  • 상장 의약품 수:

    5 상세

  • 임상 의약품 수:

    65 상세

  • 최고 개발 단계:

    Approved

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