Human CD206 / MMR Protein, His Tag, low endotoxin (MALS verified)

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Cat. No. / Size
Price
Qty
CD6-H52H9-100ug
$435.00
CD6-H52H9-1mg
$3295.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    MMR, CD206, hMR, MRC1, CLEC13D, CLEC13DL, MRC1L1

  • Source

    Human CD206, His Tag (CD6-H52H9) is expressed from human 293 cells (HEK293). It contains AA Leu 19 - Ala 1389 (Accession # P22897-1).

    Predicted N-terminus: Leu 19

    Request for sequence
  • Molecular Characterization

    CD206 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 158.6 kDa. The protein migrates as 150-190 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    CD206 SDS-PAGE

    Human CD206, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    CD206 SEC-MALS

    The purity of Human CD206, His Tag (Cat. No. CD6-H52H9) is more than 95% and the molecular weight of this protein is around 185-230 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     CD206 ELISA

    Immobilized Mannan from Saccharomyces cerevisiae at 20 μg/mL (100 μL/well) can bind Human CD206, His Tag (Cat. No. CD6-H52H9) with a linear range of 0.156-2.5 μg/mL (QC tested).

    Protocol

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Background

Mrc1 is a conserved checkpoint mediator protein that transduces the replication stress signal to the downstream effector kinase. Mrc1 and its vertebrate homologue Claspin serve as a mediator for replication stress checkpoint signaling, receiving the signal from Mec1/Rad3/ATR sensor kinase and transmitting it to the effector Rad53/Cds1/Chk1 kinase. The loss of mrc1 checkpoint activity results in the aberrant activation of late/dormant origins in the presence of hydroxyurea. Tumor-associated macrophages (TAMs) expressing the multi-ligand endocytic receptor mannose receptor (CD206/MRC1) contribute to tumor immunosuppression, angiogenesis, metastasis, and relapse.

Recent Advances

 
Drug Development Progress
  • English Name:

    Macrophage mannose receptor 1

  • Category:

  • Approved Drugs:

    1 Details

  • Drugs in Clinical Trials:

    2 Details

  • Highest Development Stage:

    Approved

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