Human Activin RIIB / ACVR2B Protein, His Tag, low endotoxin (MALS & SPR verified)

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제품 번호/규격
가격
수량
ACB-H5226-200ug
$340.00
ACB-H5226-1mg (500ug X 2)
$1450.00
ETA of in-stock products:2 business days
총 항목 수 제품 금액$ 0

제품 세부정보

  • Synonyms

    ACVR2B, ACTRIIB, MGC116908

  • Source

    Human Activin RIIB, His Tag (ACB-H5226) is expressed from human 293 cells (HEK293). It contains AA Ser 19 - Thr 137 (Accession # Q13705-1 ).

    Predicted N-terminus: Ser 19

    Request for sequence
  • Molecular Characterization

    Activin RIIB Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 14.5 kDa. The protein migrates as 20-35 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

고객님도 확인한 상품

데이터 표시

  • SDS-PAGE

    Activin RIIB SDS-PAGE

    Human Activin RIIB, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    Activin RIIB SEC-MALS

    The purity of Human Activin RIIB, His Tag (Cat. No. ACB-H5226) is more than 90% and the molecular weight of this protein is around 18-25 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     Activin RIIB ELISA

    Immobilized Human Activin RIIB, His Tag (Cat. No. ACB-H5226) at 1 μg/mL (100 μL/well) can bind Bimagrumab with a linear range of 0.05-2 ng/mL (Routinely tested).

    Protocol
  • Bioactivity-SPR

     Activin RIIB SPR

    Human Activin RIIB, His Tag (Cat. No. ACB-H5226) immobilized on CM5 Chip can bind Human Activin A, premium grade (Cat. No. ACA-H421b) with an affinity constant of 0.164 nM as determined in a SPR assay (Biacore 8K) (QC tested).

    Protocol

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배경 소개

Activin receptor type-2B (ACVR2B) is also known as ActR-IIB and MGC116908, ACVR2B is an activin type 2 receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. Defects in ACVR2B are the cause of visceral heterotaxy autosomal type 4 (HTX4).

프론티어 진행

 
의약품 개발 진행
  • 영어 이름:

    Activin receptor type-2B

  • 카테고리:

  • 상장 의약품 수:

    0 상세

  • 임상 의약품 수:

    5 상세

  • 최고 개발 단계:

    Phase 2 Clinical

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