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Product Details
- ProductSizeAmountCellectra™ Human CD3 NanoDeplet Microbeads, Research grade2 mLFor 10⁹ total cells
Product Description
Cellectra™ Human CD3 NanoDeplet Microbeads, Research grade are dextran-coated superparamagnetic iron oxide nanoparticles of which the surface is conjugated with recombinant monoclonal antibodies specific to human CD3 (Isotype: mouse IgG1). They are especially designed for the depletion of CD3+ cells.
Cellectra™ Human CD3 NanoDeplet Microbeads, Research grade are produced under sterile manufacturing conditions (ISO 5), and no animal- or human-derived components are used throughout the production process. It is produced under our rigorous quality control system that includes a comprehensive set of tests including sterility and endotoxin tests.Application
Cellectra™ Human CD3 NanoDeplet Microbeads, Research grade are designed for the depletion of CD3⁺ cells from fresh or frozen human peripheral blood mononuclear cells (PBMCs). CD3E, also known as CD3 epsilon, is a member of the immunoglobulin superfamily found on mature T lymphocytes and most thymocytes. Depletion of T cells yields a purified non-T cell population suitable for diverse downstream applications. It supports the establishment of T cell-free systems to independently study innate immune cells such as NK cells, B cells, monocytes and dendritic cells for functional assays, single-cell sequencing and drug screening, eliminating experimental interference caused by T cells. The magnetic Microbeads are conjugated with monoclonal antibodies targeting human CD3 protein, enabling CD3+ cells to be labeled with the specific antibodies and magnetic particles, and separated using the separation columns and magnets.
Storage
For long term storage, the product should be stored in liquid state at -20°C or below Stability upon receipt: Stable for 24 months at -20 °C or below; Stable for 6 months at 2–8 °C under sterile conditions. Please protect from light and avoid repeated freeze-thaw cycles.
Sterility
Negative
Endotoxin
Less than 2 EU per mL by the LAL method / rFC method.
Mycoplasma
Negative
Important Note
This product is for research use only and not intended for therapeutic or in vivo diagnostic use.
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Performance Data
Application Data
Superior the depletion Performance of CD3+ Cells (Comparison with Company M)
Separation performance was evaluated using samples containing 1×10⁷ human PBMCs, processed with CD3 microbeads from Acro, Company M at recommended dosages. Negative fractions were collected, and 1×10⁶ cells from the flow through fraction were immunostained with CD3 Antibody(FITC-anti human CD3 Antibody) and 7-AAD, followed by flow cytometric analysis. Data indicated that Acro microbeads achieved a final purity of 99.50% (baseline: 43.66%). These findings validate outstanding separation performance, confirming an optimal balance of purity and recovery relative to Company M benchmarks.
Comparison of the depletion of CD3+ Cells Separation Performances.
Isolation efficacy was validated using samples containing 1×10⁷ human PBMCs processed with the recommended dosage of Cellectra™ Human CD3 NanoDeplet Microbeads, Research grade, in parallel with Company M. Comparative analysis demonstrated that Acro NanoDeplet Microbeads achieved higher cell recovery rates than Company M, while purity and cell viability were comparable to Company M.
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Recent Advances
Drug Development Progress- English Name：
T cell surface glycoprotein CD3
- Category：
- Approved Drugs：
10 Details
- Drugs in Clinical Trials：
198 Details
- Highest Development Stage：
Approved
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