PE-Labeled Monoclonal Anti-Human TIM-3 Antibody, Rabbit IgG (M1G07) (0.03% Proclin)

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Cat. No. / Size
Price
Qty
FABm042-01-200tests (50tests X 4)
$400.00
ETA of in-stock products:2 business days

Product Details

  • Source

    Monoclonal Anti-Human TIM-3 Antibody, Rabbit IgG (M1G07) is a rabbit monoclonal antibody recombinantly expressed from human 293 cells (HEK293), which provides higher batch consistency and long term security of supply.

  • Antibody Type

    Recombinant Monoclonal

  • Clone

    M1G07

  • Isotype

    Rabbit IgG, Kappa

  • Host Species

    Rabbit

  • Reactivity

    Human

  • Immunogen

    Purified Human TIM-3 Protein

  • Conjugate

    PE

    Excitation Wavelength: 488 nm / 561 nm

    Emission Wavelength: 575 nm

  • Specificity

    This product is a specific antibody specifically reacts with TIM-3 protein.

  • Application

    Flow Cytometry (Detection the expression of TIM-3 on Human cells).

  • Recommended Dilution

    1:20

  • Isotype Control

    The isotype control is sold separately; please refer to Cat. No. DNP-PFM776 for product information.

  • Form

    Liquid

  • Formulation

    Supplied as 0.2 μm-filtered solution in PBS (pH 7.4) containing 0.03% ProClin 300 and 0.2% BSA, with trehalose as protectant.

    Please contact us for customized product forms or formulations.

  • Shipping

    Liquid product is shipped at blue ice.

  • Storage

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. Store at 2-8 °C for 12 months.
  • Notices

    Product Specific Notices: For research use only.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • Bioactivity-FACS

     TIM-3 FACS

    Flow cytometric analysis of NK-92 Cells staining with PE-Labeled Monoclonal Anti-Human Tim-3 Antibody, Rabbit IgG(M1G07) (Cat. No. FABm042-01) at 1:20 dilution (5 μL of the antibody stock solution corresponds to labeling of 1e6 cells in afinal volume of 100 µL), compared with isotype control antibody. PE signal was used to evaluate the binding activity (QC tested).

    Protocol

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Background

Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428, KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.

Recent Advances

 
Drug Development Progress
  • English Name:

    Hepatitis A virus cellular receptor 2

  • Category:

  • Approved Drugs:

    0 Details

  • Drugs in Clinical Trials:

    23 Details

  • Highest Development Stage:

    Phase 3 Clinical

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