Monoclonal Anti-Hantaan virus pre-Gc protein Antibody, Human IgG1 (6D5) (MALS verified)

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Cat. No. / Size
Price
Qty
PRN-MY322-100ug
$415.00
PRN-MY322-1mg (500ug X 2)
$2735.00
ETA of in-stock products:2 business days

Product Details

  • Source

    Monoclonal Anti-Hantaan virus pre-Gc protein Antibody, Human IgG1 (6D5) is a chimeric monoclonal antibody recombinantly expressed in HEK293, which combines the variable region of a mouse monoclonal antibody with human constant domain.

  • Antibody Type

    Recombinant Monoclonal

  • Clone

    6D5

  • Isotype

    Human IgG1, Kappa

  • Host Species

    Mouse

  • Reactivity

    Hantaan virus (strain 76-118) (Korean hemorrhagic fever virus)

  • Immunogen

    Recombinant Hantaan virus (strain 76-118) (Korean hemorrhagic fever virus) pre-Gc protein is expressed from human HEK293 cells

  • Specificity

    Specifically recognizes Hantaan virus (strain 76-118) (Korean hemorrhagic fever virus) pre-Gc protein Protein.

  • Purification

    Protein A purified / Protein G purified.

  • Aggregation

    Less than 10%, as determined by SEC-MALS.

  • Concentration

    Please refer to the Certificate of Analysis (CoA).

  • Form

    Lyophilized

  • Formulation

    Lyophilized from a 0.22 μm-filtered solution in PBS (pH 7.4), with trehalose as protectant.

    Please contact us for customized product forms or formulations.

  • Reconstitution

    Please refer to the Certificate of Analysis (CoA) for specific instructions.

  • Shipping

    Lyophilized product is shipped at ambient temperature.

  • Storage

    For long term storage, the product should be stored in a lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • Notices

    Product Specific Notices: For research use only.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • Bioactivity-ELISA

     pre-Gc protein ELISA

    Immobilized Hantaan virus (strain 76-118) (Korean hemorrhagic fever virus) pre-Gc protein, His Tag (Cat. No. PRN-V52H4) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Hantaan virus pre-Gc protein Antibody, Human IgG1 (6D5) (Cat. No. PRN-MY322) with a linear range of 0.05-2 ng/mL (QC tested).

    Protocol

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FAQ

  • Product

    What do “pre” and “post” refer to in the names of viral proteins?

    In virology, “pre” refers to the conformation of a viral surface glycoprotein before fusion with the host cell membrane, while “post” refers to the conformation after membrane fusion and entry into the host cell. Both are naturally occurring states in the viral life cycle. Because the “pre” conformation represents a critical stage before viral entry, antibodies designed against this state often exhibit stronger neutralizing activity and are therefore more effective in preventing infection.

Background

Hantaviruses (genus Orthohantavirus) are enveloped, negative-sense, single-stranded ribonucleic acid (RNA) viruses. The genomes of hantaviruses are composed of tri-segmented single-stranded, negative sense RNA, designated as small (S), medium (M) and large (L) segments. Each segment encodes nucleocapsid protein (NP), glycoprotein precursor (GPC) and RNA-dependent RNA polymerase (RdRp), respectively. GPC is posttranslationally cleaved into Gn and Gc. Glycoproteins Gn and Gc are transmembrane proteins and constitute an envelope with a lipid membrane derived from host cells. Gn and Gc are involved in receptor binding, membrane fusion and induction of protective immunity. The two glycoproteins are presumed to be the major elements involved in the induction of neutralizing antibodies during hantavirus infection.

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