제품 수집
제품 세부정보
Background
Recombinant Monoclonal Anti-Claudin-18.2 Antibody, Mouse (3B10) is a Claudin-18.2 primary antibody for IHC application. The Claudin-18.2 (CLDN 18.2) protein, an isoform of Claudin 18, a member of the tight junction protein family, is a highly selective biomarker with limited expression in normal tissues and often abnormal expression during the occurrence and development of various primary malignant tumors, such as gastric cancer/gastroesophageal junction (GC/GEJ) cancer, breast cancer, colon cancer, liver cancer, head and neck cancer, bronchial cancer and non-small-cell lung cancer. Claudin-18.2 participates in the proliferation, differentiation and migration of tumor cells. Recent studies have identified Claudin-18.2 expression as a potential specific marker for the diagnosis and treatment of these tumors.
Product Specifications
Host SpeciesMouseIsotypeMouse IgG1, Mouse KappaClone3B10ApplicationIHC-PDilution Ratio1: 500 - 1: 2000FormLiquidClonalityMonoclonalReactivityHumanSynonymsCLDN 18.2Concentration0.6~0.9 mg/mlSpecificityReact with Claudin 18.2 protein on the membrane of target cell/tissue; No cross reactivity with Claudin 18.1Purification TechProtein GPreservationPBS, 10% Trehalose (pH7.4)Experiment Protocol
Storage
Shipped at 4°C, Blue Ice. Store at +4°C for short term (1-2 weeks). Store at -20°C for long term.
Avoid freeze / thaw cycle. Upon delivery aliquot. The shelf life is 30 days from the date of opening.ACRO Quality Management System
고객님도 확인한 상품
데이터 표시
Sample Staining Data
Immunohistochemical analysis of paraffin embedded human gastric cancer tissue labelled with HCS-S278 at 1/1000 dilution. Membranous staining on tumor cells is observed.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with LEICA BOND IHC staining protocol.
Immunohistochemical analysis of paraffin embedded human pancreatic cancer tissue labelled with HCS-S278 at 1/1000 dilution. Membranous staining on tumor cells is observed.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with LEICA BOND IHC staining protocol.
Immunohistochemical analysis of paraffin embedded human colorectal cancer tissue labelled with HCS-S278 at 1/1000 dilution. Membranous staining on tumor cells is observed.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with LEICA BOND IHC staining protocol.
Immunohistochemical analysis of paraffin embedded human stomach tissue labelled with HCS-S278 at 1/1000 dilution, demonstrating postive staining.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with LEICA BOND IHC staining protocol.
Immunohistochemical analysis of paraffin embedded human lung tissue labelled with HCS-S278 at 1/1000 dilution, demonstrating negative staining, which indicating no reactivity with Claudin 18.1 protein in the tissue level.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with LEICA BOND IHC staining protocol.
사용자 리뷰 댓글 남기기
프론티어 진행
의약품 개발 진행- 영어 이름：
Claudin-18 splice variant 2
- 카테고리：
- 상장 의약품 수：
1 상세
- 임상 의약품 수：
82 상세
- 최고 개발 단계：
Approved
연락하기
전화
글로벌: +1 800-810-0816 (무료)
아시아태평양: +86 400-682-2521
신약 후보물질 라이선싱
