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PE-Labeled Monoclonal Anti-Human CD5 Antibody, Mouse IgG1 (2C8A7) (0.03% Proclin)

COADS MS
DS

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Cat. No. / Size
Price
Qty
FABm032-01-50tests
$200.00
FABm032-01-200tests (50tests X 4)
$720.00
ETA of in-stock products:2 business days
Sub-Total$ 0
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Product Details

  • Source

    Monoclonal Anti-Human CD5 Antibody, Mouse IgG1 (2C8A7) is a mouse monoclonal antibody produced from hybridoma.

  • Clone

    2C8A7

  • Isotype

    Mouse IgG1, Kappa

  • Host Species

    Mouse

  • Reactivity

    Human

  • Immunogen

    Purified Human CD5 Protein

  • Conjugate

    PE

    Excitation Wavelength: 488 nm / 561 nm

    Emission Wavelength: 575 nm

  • Specificity

    This product is a specific antibody specifically reacts with CD5 protein.

  • Application

    Flow Cytometry (Evaluation of the expression of CD5 on Human cells).

  • Recommended Dilution

    1:20

  • Isotype Control

    The isotype control is sold separately; please refer to Cat. No. DNP-PM1 for product information.

  • Form

    Liquid

  • Formulation

    Supplied as 0.2 μm-filtered solution in PBS (pH 7.4) containing 0.03% ProClin 300 and 0.2% BSA, with trehalose as protectant.

    Please contact us for customized product forms or formulations.

  • Shipping

    Liquid product is shipped at blue ice.

  • Storage

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. Store at 2-8 °C for 12 months.

  • Notices

    Product Specific Notices: For research use only.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • Bioactivity-FACS

    CD5 FACS

    Flow cytometric analysis of Jurkat staining with Anti-Human CD5 Antibody, Mouse IgG1 (2C8A7) (Cat. No. FABm032-01) FACS Protocol at 1:20 dilution (5 μL of the antibody stock solution corresponds to labeling of 1e6 cells in a final volume of 100 µL), compared with isotype control antibody. PE signal was used to evaluate the binding activity (QC tested).

    Protocol

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Background

T-cell surface glycoprotein CD5 is also known as Lymphocyte antigen T1/Leu-1 and LEU1,which is phosphorylated on tyrosine residues by LYN,so CD5 can create binding sites for PTPN6/SHP-1.CD5 may act as a receptor in regulating T-cell proliferation. CD5 is expressed at various developmental and activation stages on human B cells.CD5 is a well established negative regulator of TCR and BCR signalling.CD5-positive cells may also prevent the emergence of autoimmunity by provision of cytokines such as IL-10. Development,selection and function of different B- and T-cell subsets or their preferential survival may be directly or indirectly dependent on different glycan structures associated with CD5 or CD5-like molecules.

Recent Advances

 
Drug Development Progress
  • English Name：

    T-cell surface glycoprotein CD5

  • Category：

  • Approved Drugs：

    0 Details

  • Drugs in Clinical Trials：

    13 Details

  • Highest Development Stage：

    Phase 2 Clinical

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