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Microelectrode Array (MEA) Service

MEA is an advanced electrophysiological detection technology that uses multiple microelectrodes embedded on the surface of culture plates to simultaneously monitor and record electrical signals from multiple cells. These electrodes are in close contact with the cells, allowing electrical signals generated by the cells to be transmitted through the cell-electrode interface and captured by the MEA system as analyzable data. With its efficiency, non-invasiveness, and ability for long-term continuous monitoring, MEA technology is a powerful tool for research in neuroscience, developmental biology, and drug development.

Microelectrode Array (MEA) Service
Microelectrode Array (MEA) Technology

What You Can Do with ACRO's MEA System

Main Technical Parameters:

Stable Environment Control: Ensures consistent CO2 and temperature conditions.
High-Speed Data Collection: 12.5 KHz rate for accurate depolarization waveform analysis.
Sensitive Voltage Resolution: Detects subtle extracellular action potentials.
High-Density Electrode Array: The Maestro Porous plate's 24 x 16 electrodes provide high-quality data for entire culture plates.
Flexible Plate Options: Available in 6- and 24-well formats to accommodate diverse cell culture needs.
Advanced Signal Processing Chip: BioCore V4 chip offers strong signals, low-frequency capacity, and flexibility.

ACRO’s Service Offerings:

Organoid Electrophysiology Monitoring: Records ECG, spontaneous signals, and responses to various stimuli.
2D Cell Signal Detection: Captures spontaneous electrical signals and changes after stimulation.
Comprehensive Reporting: Provides a detailed MEA assay report, raw data, and images.

Maestro Edge MEA assay
system

Cerebral organoids generate
spontaneous spikes and bursts

Cardiac organoid
tested for the ECG

Why ACRO:

Accurate, Non-Invasive Data Collection: Record extracellular voltage of electroactive cells without labeling or invasiveness, preserving their natural state.
Optimized Experimental Environment: Ensure stable CO2 and temperature control for reliable short- and long-term studies.
Industry-Leading Organoid Electrophysiology Detection: We have successfully applied the MEA recording system to cardiac and cerebral organoids, allowing us to test ECG and the generation and transmission of nerve electrical signals in the brain.

Case Study

MEA Verified Haloperidol-Induced Modulation of Neuronal Firing

MEA Verified Haloperidol-Induced Modulation of Neuronal Firing

This data set demonstrates the dose-dependent effects of Haloperidol on neuronal firing. Raster plots and associated firing parameters (for Weighted Mean Firing Rate, Number of Bursts, Burst Duration and Burst Frequency, n = 3; for Number of Network Bursts, n = 2) are presented for varying Haloperidol concentrations. At 0.1 μM, the firing activity is enhanced, while at 1 μM, the activity diminishes. At 10 μM, the firing is nearly abolished. These results are consistent with findings from Yokoi et al. (2019), where Haloperidol is known to inhibit D2 receptors at low doses and 5-HT2 receptors at high doses (Tyler et al., 2017). This confirms that the relevant receptors in our Human iPSC-Derived Dopamine Neurons are functioning normally, underscoring their utility in drug screening and neurotoxicity studies.

  • Introduction
  • What You Can Do with ACRO's MEA System
  • Case Study
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[North America]: 1 Innovation Way, Newark, DE 19711, USA [Switzerland]: ACRObiosystems AG, c/o Zug Dammstrasse Centre AG, Dammstrasse 19, 6300 Zug Switzerland

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