Human CXCL2 Protein, Fc Tag (MALS & SPR verified)

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제품 번호/규격
가격
수량
CX2-H5253-100ug
$360.00
CX2-H5253-1mg
$2380.00
ETA of in-stock products:2 business days
총 항목 수 제품 금액$ 0

제품 세부정보

  • Synonym

    C-X-C motif chemokine 2, Growth-regulated protein beta, Gro-beta, Macrophage inflammatory protein 2-alpha, MIP2-alpha, GRO2, GROB, MIP2A, SCYB2

  • Source

    Human CXCL2, Fc Tag (CX2-H5253) is expressed from human 293 cells (HEK293). It contains AA Ala 35 - Asn 107 (Accession # P19875).

    Predicted N-terminus: Ala 35

    Request for sequence
  • Molecular Characterization

    CXCL2 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 34.3 kDa. The protein migrates as 38-42 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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데이터 표시

  • SDS-PAGE

    CXCL2 SDS-PAGE

    Human CXCL2, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • SEC-MALS

    CXCL2 SEC-MALS

    The purity of Human CXCL2, Fc Tag (Cat. No. CX2-H5253) is more than 90% and the molecular weight of this protein is around 60-75 kDa verified by SEC-MALS.

    Report
  • Bioactivity-SPR

     CXCL2 SPR

    Human CXCR2 Protein, Flag,His Tag (Cat. No. CX2-H55D3) immobilized on CM5 Chip can bind Human CXCL2, Fc Tag (Cat. No. CX2-H5253) with an affinity constant of 8.12 nM as determined in a SPR assay (in presence of DDM and CHS) (Biacore 8K) (QC tested).

    Protocol

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배경 소개

Chemokine (C-X-C motif) ligand 2 (CXCL2) is a small cytokine belonging to the CXC chemokine family that is also called macrophage inflammatory protein 2-alpha (MIP2-alpha), Growth-regulated protein beta (Gro-beta) and Gro oncogene-2 (Gro-2). CXCL2 is 90% identical in amino acid sequence as a related chemokine, CXCL1. This chemokine is secreted by monocytes and macrophages and is chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells.CXCL2 mobilizes cells by interacting with a cell surface chemokine receptor called CXCR2.CXCL2, like related chemokines, is also a powerful neutrophil chemoattractant and is involved in many immune responses including wound healing, cancer metastasis, and angiogenesis.

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