Human CLEC12A / MICL / CLL-1 Protein, Fc Tag, low endotoxin (MALS verified)

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CLA-H5266-50ug
$380.00
CLA-H5266-1mg (500ug X 2)
$3095.00
ETA of in-stock products:2 business days
총 항목 수 제품 금액$ 0

제품 세부정보

  • Synonym

    CLEC12A, MICL, CLL-1, CLL1, DCAL2, DCAL-2, CD371

  • Source

    Human CLEC12A, Fc Tag (CLA-H5266) is expressed from human 293 cells (HEK293). It contains AA His 65 - Ala 265 (Accession # Q5QGZ9-2).

    Predicted N-terminus: Pro

    Request for sequence
  • Molecular Characterization

    CLEC12A Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the N-terminus.

    The protein has a calculated MW of 50.2 kDa. The protein migrates as 55-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

고객님도 확인한 상품

데이터 표시

  • SDS-PAGE

    CLEC12A SDS-PAGE

    Human CLEC12A, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • SEC-MALS

    CLEC12A SEC-MALS

    The purity of Human CLEC12A, Fc Tag (Cat. No. CLA-H5266) is more than 95% and the molecular weight of this protein is around 125-140 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     CLEC12A ELISA

    Immobilized Human CLEC12A, Fc Tag (Cat. No. CLA-H5266) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Human CLEC12A Antibody, Human IgG1 with a linear range of 0.1-4 ng/mL (QC tested).

    Protocol
  • Bioactivity-FACS

     CLEC12A FACS

    2e5 of anti-CLEC12A CAR-293 cells were stained with 100μL of 3 μg/mL of Human CLEC12A, Fc Tag (Cat. No. CLA-H5266) and negative control protein respectively, washed and then followed by PE anti-human IgG Fc antibody and analyzed with FACS (Routinely tested).

    Protocol

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배경 소개

CLEC12A (C-type lectin domain family 12 member A) is also known as CLL1, DCAL2, MICL. Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death. Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. Evidence of distinct disease propagating stem cells in myelodysplastic syndrome (MDS) has emerged in recent years. The role of CLEC12A in MDS, however, remains to be elucidated. Furthermore, CLEC12A has been proposed as a promising marker of leukaemic stem cells in AML.

프론티어 진행

 
의약품 개발 진행
  • 영어 이름:

    C-Type lectin domain family 12 member A

  • 카테고리:

  • 상장 의약품 수:

    0 상세

  • 임상 의약품 수:

    26 상세

  • 최고 개발 단계:

    Phase 2 Clinical

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