Human CD98 Protein, Fc Tag, low Endotoxin (MALS verified)

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제품 번호/규격
가격
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CD8-H5263-100ug
$315.00
CD8-H5263-1mg (500ug X 2)
$2215.00
ETA of in-stock products:2 business days
총 항목 수 제품 금액$ 0

제품 세부정보

  • Synonym

    SLC3A2, CD98, 4F2, 4F2HC, 4T2HC, CD98HC, MDU1, NACAE

  • Source

    Human CD98 Protein, Fc Tag (CD8-H5263) is expressed from human 293 cells (HEK293). It contains AA Arg 206 - Ala 630 (Accession # P08195-1).

    Predicted N-terminus: Pro

    Request for sequence
  • Molecular Characterization

    CD98 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the N-terminus.

    The protein has a calculated MW of 73.3 kDa. The protein migrates as 80-100 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

고객님도 확인한 상품

데이터 표시

  • SDS-PAGE

    CD98 SDS-PAGE

    Human CD98 Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    CD98 SEC-MALS

    The purity of Human CD98 Protein, Fc Tag (Cat. No. CD8-H5263) is more than 90% and the molecular weight of this protein is around 150-180 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     CD98 ELISA

    Immobilized Human CD98 Protein, Fc Tag (Cat. No. CD8-H5263) at 1 μg/mL (100 μL/well) can bind CD98 Recombinant Rabbit Monoclonal Antibody with a linear range of 0.05-2 ng/mL (QC tested).

    Protocol

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배경 소개

CD antigen CD98 is also known as 4F2 cell-surface antigen heavy chain (4F2hc), 4F2 heavy chain antigen, Solute carrier family 3 member 2 (SLC3A2), Lymphocyte activation antigen 4F2 large subunit, is a single-pass type I I membrane protein which belongs to the SLC3A transporter family.. SLC3A2 / CD98 is expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. SLC3A2 / CD98 is required for the function of light chain amino-acid transporters and also involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. CD98 involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A5 or SLC7A8, CD98 involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals.

프론티어 진행

 
의약품 개발 진행
  • 영어 이름:

    L-type amino acid transporter 1

  • 카테고리:

  • 상장 의약품 수:

    0 상세

  • 임상 의약품 수:

    7 상세

  • 최고 개발 단계:

    NDA/BLA

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