Human CD8 alpha Protein, Fc Tag, low endotoxin (MALS verified)

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제품 번호/규격
가격
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CDA-H5258-100ug
$450.00
CDA-H5258-1mg
$2980.00
ETA of in-stock products:2 business days
총 항목 수 제품 금액$ 0

제품 세부정보

  • Synonym

    CD8A, CD8, Leu2, MAL, p32

  • Source

    Human CD8 alpha Protein, Fc Tag (CDA-H5258) is expressed from human 293 cells (HEK293). It contains AA Ser 22 - Asp 182 (Accession # P01732-1).

    Predicted N-terminus: Ser 22

    Request for sequence
  • Molecular Characterization

    CD8 alpha Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 44.1 kDa. The protein migrates as 53-58 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

고객님도 확인한 상품

데이터 표시

  • SDS-PAGE

    CD8 alpha SDS-PAGE

    Human CD8 alpha Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    CD8 alpha SEC-MALS

    The purity of Human CD8 alpha Protein, Fc Tag (Cat. No. CDA-H5258) is more than 95% and the molecular weight of this protein is around 90-120 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     CD8 alpha ELISA

    Immobilized Human CD8 alpha Protein, Fc Tag (Cat. No. CDA-H5258) at 1 μg/mL (100 μL/well) can bind Anti-CD8 alpha Antibody, Human IgG1 with a linear range of 0.2-8 ng/mL (QC tested).

    Protocol

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배경 소개

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.

프론티어 진행

 
의약품 개발 진행
  • 영어 이름:

    Cluster of differentiation 8

  • 카테고리:

  • 상장 의약품 수:

    0 상세

  • 임상 의약품 수:

    18 상세

  • 최고 개발 단계:

    Phase 3 Clinical

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