Cynomolgus CD8 alpha / CD8A Protein, His Tag, low endotoxin (MALS verified)

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CDA-C52H4-50ug
$360.00
CDA-C52H4-1mg (500ug X 2)
$2945.00
ETA of in-stock products:2 business days
총 항목 수 제품 금액$ 0

제품 세부정보

  • Synonym

    CD8A, CD8, Leu2, MAL, p32

  • Source

    Cynomolgus CD8 alpha Protein, His Tag (CDA-C52H4) is expressed from human 293 cells (HEK293). It contains AA Asn 63 - Asp 223 (Accession # XP_005575419.2).

    Predicted N-terminus: Asn 63

    Request for sequence
  • Molecular Characterization

    CD8 alpha Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 19.6 kDa. The protein migrates as 20-30 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

    The protein is designed as a dimer.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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데이터 표시

  • SDS-PAGE

    CD8 alpha SDS-PAGE

    Cynomolgus CD8 alpha Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    CD8 alpha SEC-MALS

    The purity of Cynomolgus CD8 alpha Protein, His Tag (Cat. No. CDA-C52H4) is more than 95% and the molecular weight of this protein is around 46-56 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     CD8 alpha ELISA

    Immobilized Cynomolgus CD8 alpha Protein, His Tag (Cat. No. CDA-C52H4) at 5 μg/mL (100 μL/well) can bind Anti-CD8 alpha Antibody, Human IgG1 with a linear range of 0.1-8 ng/mL (QC tested).

    Protocol

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배경 소개

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.

프론티어 진행

 
의약품 개발 진행
  • 영어 이름:

    Cluster of differentiation 8

  • 카테고리:

  • 상장 의약품 수:

    0 상세

  • 임상 의약품 수:

    18 상세

  • 최고 개발 단계:

    Phase 3 Clinical

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