Mouse CD79B Protein, His Tag, low endotoxin (MALS verified)

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Cat. No. / Size
Price
Qty
CDB-M52H4-100ug
$395.00
CDB-M52H4-1mg (250ug X 4)
$2615.00
ETA of in-stock products:2 business days

Product Details

  • Synonym

    CD79b, B29, IGB, Ig-beta

  • Source

    Mouse CD79B Protein, His Tag (CDB-M52H4) is expressed from human 293 cells (HEK293). It contains AA Val 26 - Asp 158 (Accession # P15530-1).

    Predicted N-terminus: Val 26

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  • Molecular Characterization

    CD79B Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 17.0 kDa. The protein migrates as 28-38 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, 0.2 M Arginine, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    CD79B SDS-PAGE

    Mouse CD79B Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

  • SEC-MALS

    CD79B SEC-MALS

    The purity of Mouse CD79B Protein, His Tag (Cat. No. CDB-M52H4) is more than 85% and the molecular weight of this protein is around 25-40 kDa verified by SEC-MALS.

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Background

B-cell antigen receptor complex-associated protein beta chain (CD79b) is also known as B-cell-specific glycoprotein B29, Ig-beta,Immunoglobulin-associated B29 protein, B29 and IGB, which is a single-pass type I membrane protein containing one Ig-like V-type ( immunoglobulin-like ) domain and one ITAM domain.CD79b is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR).CD79b can enhance phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Defects in CD79b are the cause of agammaglobulinemia type 6 (AGM6) that is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development.

Recent Advances

 
Drug Development Progress
  • English Name:

    B-cell antigen receptor complex-associated protein beta chain

  • Category:

  • Approved Drugs:

    1 Details

  • Drugs in Clinical Trials:

    9 Details

  • Highest Development Stage:

    Approved

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