Human CCR8 Full Length Protein, His,Flag Tag (Nanodisc-pro)

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사용자 리뷰
제품 번호/규격
가격
수량
CC8-H52D4-20ug
$ 750.00
CC8-H52D4-100ug
$ 1500.00
CC8-H52D4-500ug
$ 4800.00
총 항목 수 제품 금액$ 0

제품 세부정보

  • Application

    1. Immunization
    2. Cell based assay (FACS or functional assay)
    3. Affinity testing (SPR / BLI)
    4. Screening (ELISA)
  • Synonym

    CC chemokine receptor 8, CDw198, ChemR1, CKRL1, CKR-L1, CKRL1, CY6, GPRCL1, GPRCY6, GPR-CY6, TER-1

  • Source

    Nanodisc-pro Human CCR8 Full Length Protein, His,Flag Tag (CC8-H52D4) is expressed from human 293 cells (HEK293). It contains AA Asp 2 - Ser 345 (Accession # P51685-1 ).

  • Molecular Characterization

    CCR8 Structure

    Other Tags and Version Biotin & Other Labeled Version

    1. Structure

      Nanodisc-pro membrane protein is wrapped by a piece of cell membrane and copolymer.

    2. Synthesis Process

      Nanodisc-pro membrane protein extraction is a gentle, non-disruptive process that directly isolates full-length transmembrane proteins together with their surrounding native phospholipids from cellular membranes, without breaking or disturbing the original membrane structure. This preserves the membrane protein's natural conformational landscape and native lipid environment, yielding stable nanodisc that retain cellular phospholipids and eliminate the need for detergent solubilization, with fully preserved biological activity—making them ideal for cell-based assays such as FACS and binding assays in antibody discovery and screening (ELISA), etc.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Formulation

    Please contact us for detailed information.

    Contact us for customized product form or formulation.

  • Shipping

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • Storage

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process
  • *The isotype control of empty/mock nanodisc (Cat. No. APO-H5143) is sold separately and not included in protein, you can follow the link for product information.

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배경 소개

A chemokine receptor predominantly marking tumor-infiltrating regulatory T cells (Tregs) rather than peripheral Tregs. Targeting CCR8 enables selective depletion of immunosuppressive cells within the tumor microenvironment, thereby reinvigorating anti-tumor immunity without triggering systemic autoimmunity.

프론티어 진행

 
의약품 개발 진행
  • 영어 이름:

    C-C chemokine receptor type 8

  • 카테고리:

  • 상장 의약품 수:

    0 상세

  • 임상 의약품 수:

    20 상세

  • 최고 개발 단계:

    Phase 3 Clinical

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