Human CCR2 Full Length Protein (VLP)

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제품 번호/규격
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CC2-H52P3-20ug
$620.00
CC2-H52P3-100ug
$1235.00
CC2-H52P3-500ug (250ug X 2)
$4305.00
ETA of in-stock products:2 business days
총 항목 수 제품 금액$ 0

제품 세부정보

  • Application

    1. Immunization
    2. FACS
    3. Elisa
  • Synonym

    C-C chemokine receptor type 2, C-C CKR-2, CC-CKR-2, CC-CKR-2CKR2B, CCR2, CCR-2, CCR2A, CCR2B, CD192 antigen, CD192, chemokine (C-C motif) receptor 2, CKR2, CKR2A, CMKBR2, CMKBR2MGC111760, FLJ78302, MCP-1 receptor, MCP-1-R, MCP-1-RMGC103828, MGC168006, Monocyte chemoattractant protein 1 receptor, monocyte chemotactic protein 1 receptor

  • Source

    Human CCR2 Full Length Protein (VLP) (CC2-H52P3) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Leu 360 (Accession # P41597-2).

    Predicted N-terminus: Met 1

  • Molecular Characterization

    1. Structure

      Virus-like particles (VLPs) are protein particles that mimic the shape of viruses but lack a viral genome, and incorporating transmembrane proteins on the external surface.

    2. Synthesis Process

      Virus-like particles (VLPs) are non-infectious structures that mimic the shape of viruses but lack a viral genome. During VLP production in cells systems, VLPs self-assemble into 100-200 nm protein particles, and incorporate transmembrane proteins into a VLP-MP complex, resulting in presentation of the protein on the external surface of the VLP. Their repetitive, multivalent surface display and strong immunogenicity, making them an excellent candidate for immunization.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Formulation

    The VLPs are highly immunogenic, so the immunization strategy should be optimized (antigen dose, regimen and adjuvant).

    Supplied as 0.2 μm filtered solution in PBS, pH7.4 with glycerol as protectant.

    Contact us for customized product form or formulation.

  • Shipping

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • Storage

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 12 months under sterile conditions.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process
  • *The isotype control of empty/mock VLP (Cat. No. VLP-N5213) is sold separately and not included in protein, you can follow the link for product information.

고객님도 확인한 상품

데이터 표시

  • Bioactivity-ELISA

     CCR2 ELISA

    Immobilized Human CCR2 Full Length Protein (VLP) (Cat. No. CC2-H52P3) at 5 μg/mL (100 μL/well) can bind Anti-CCR2 antibody with a linear range of 0.5-8 ng/mL (QC tested).

    Protocol
  • Identity-DLS

     CCR2 DLS

    The mean peak Radius of VLP is 80-120 nm with more than 95% intensity as determined by dynamic light scattering (DLS).

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배경 소개

The primary receptor for CCL2 (MCP-1), a major chemokine driving monocyte egress from bone marrow and recruitment to inflamed tissues. The CCR2-CCL2 axis promotes tumor-associated macrophage (TAM) accumulation and fibrosis. Antagonists aim to reprogram the immunosuppressive tumor stroma and treat inflammatory diseases.

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