Cynomolgus / Rhesus macaque BCMA / TNFRSF17 Protein, Llama IgG2b Fc Tag, low Endotoxin (MALS verified)

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제품 번호/규격
가격
수량
BCA-C5257-100ug
$360.00
BCA-C5257-1mg
$2615.00
ETA of in-stock products:2 business days
총 항목 수 제품 금액$ 0

제품 세부정보

  • Synonym

    TNFRSF17, CD269, BCM, BCMA

  • Source

    Cynomolgus / Rhesus macaque BCMA, Llama IgG2b Fc Tag (BCA-C5257) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ala 53 (Accession # A0A2K5UD97-1). In the region Met 1 - Ala 53, the AA sequence of Cynomolgus and Rhesus macaque BCMA are homologus.

    Predicted N-terminus: Met 1

    Request for sequence

  • Molecular Characterization

    BCMA Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a llama IgG2b Fc tag at the C-terminus.

    The protein has a calculated MW of 33.8 kDa. The protein migrates as 40-48 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

고객님도 확인한 상품

데이터 표시

  • SDS-PAGE

    BCMA SDS-PAGE

    Cynomolgus / Rhesus macaque BCMA, Llama IgG2b Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • SEC-MALS

    BCMA SEC-MALS

    The purity of Cynomolgus / Rhesus macaque BCMA, Llama IgG2b Fc Tag (Cat. No. BCA-C5257) is more than 95% and the molecular weight of this protein is around 65-88 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     BCMA ELISA

    Immobilized Cynomolgus / Rhesus macaque BCMA, Llama IgG2b Fc Tag (Cat. No. BCA-C5257) at 5 μg/mL (100 μL/well) can bind Biotinylated Human BAFF, Avitag,Fc Tag (active trimer) (MALS verified) (Cat. No. BAF-H82F3) with a linear range of 0.1-8 ng/mL (QC tested).

    Protocol
  •  BCMA ELISA

    Immobilized Human APRIL, His,Flag Tag, active trimer (Cat. No. APL-H52D1) at 5 μg/mL (100 μL/well) can bind Cynomolgus / Rhesus macaque BCMA, Llama IgG2b Fc Tag (Cat. No. BCA-C5257) with a linear range of 0.1-8 ng/mL (Routinely tested).

    Protocol

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배경 소개

Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) is also known as B-cell maturation protein (BCMA), CD antigen CD269, which is a member of the TNF-receptor superfamily. TNFRSF17 contains one TNFR-Cys repeat. TNFRSF17 is expressed in mature B-cells, but not in T-cells or monocytes. TNFRSF17 is receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. TNFRSF17 promotes B-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 can activate NF-kappa-B and JNK.

프론티어 진행

 
의약품 개발 진행
  • 영어 이름:

    B-cell maturation protein

  • 카테고리:

  • 상장 의약품 수:

    8 상세

  • 임상 의약품 수:

    145 상세

  • 최고 개발 단계:

    Approved

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  • 데이터 표시
  • 사용자 리뷰
  • 배경
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