IFN-beta

IFN-beta

IFN-beta Overview

Molecule Name
Interferon beta
Synonyms
IFNB1,Interferon beta,IFN-beta,IFB,IFNB
Drug Development Progress
Drugs in Clinical Trials6
Approved Drugs1
Highest Development StageApproved
Target Synonym
Interferon Beta 1,Interferon, Beta 1, Fibroblast,IFNB,IFB,IFF,Interferon-beta,IFN-beta,Fibroblast interferon,IFNB1,Interferon beta
Background
Interferon beta(IFN beta) is type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli. Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins. IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth (By similarity)

IFN-beta Product List

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Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
DazukibartPF-06823859Phase 3 ClinicalPfizer Inc
Dermatomyositis; Lupus Erythematosus, Cutaneous; Lupus Erythematosus, Systemic; Muscular Diseases; Myositis; Polymyositis
Details
Peginterferon beta-1a (CinnaGen)Phase 3 ClinicalCinnagen
Multiple Sclerosis, Relapsing-Remitting
Details
VSV-IFNbeta-NISPhase 2 ClinicalVyriad
Angioimmunoblastic T-cell Lymphoma; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colorectal Neoplasms; Endometrial Neoplasms; Histiocytoma; Leukemia, Myeloid, Acute; Lymphoma, B-Cell; Lymphoma, Large-Cell, Anaplastic; Lymphoma, T-Cell; Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral; Melanoma; Multiple Myeloma; Mycosis Fungoides; Myelodysplastic Syndromes; Sarcoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck
Details
VSV-hIFNbeta-NIS (University of Tennessee)Phase 1 ClinicalThe University Of Tennessee
Endometrial Neoplasms; Leukemia, Myeloid, Acute; Lymphoma, T-Cell; Multiple Myeloma
Details
MEM-288MEM-288Phase 1 ClinicalMemgen
Carcinoma, Merkel Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Melanoma; Neoplasm Metastasis; Neoplasms; Pancreatic Neoplasms; Solid tumours; Triple Negative Breast Neoplasms
Details
SCD-153SCD-153Phase 1 ClinicalInstitute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Johns Hopkins University, Sun Pharma Advanced Research Company Ltd
Alopecia Areata
Details

Marketed Drug Information

English NameResearch CodeHighest Development StageCompanyFirst Brand NameFirst Approved CountryFirst IndicationFirst Approved CompanyFirst Approved DateIndicationClinical Trial
PropagermaniumSK-818; SK-818CApprovedSanwa Kagaku Kenkyusho Co LtdSerocionJapanHepatitis BSanwa Kagaku Kenkyusho Co Ltd1994-01-01
Hepatitis B
Details