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Complement C5

Complement C5 분자 정보

영어 이름	Complement C5	시판 약물 수	8
임상 약물 수	20	표적 별명	C5a，Complement Component 5，ECLZB，Anaphylatoxin C5a Analog，C5a Anaphylatoxin，C5b，C5，Prepro-C5，CPAMD4，Complement C5，C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 4，C5D
최고 연구 개발 단계	Approved

영어 이름	Complement C5
표적 별명	C5a，Complement Component 5，ECLZB，Anaphylatoxin C5a Analog，C5a Anaphylatoxin，C5b，C5，Prepro-C5，CPAMD4，Complement C5，C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 4，C5D
시판 약물 수	8
임상 약물 수	20
최고 연구 개발 단계	Approved

Complement C5 제품 목록

속성
Protein (11)Kits (1)
제품 라이브러리
온라인 (12)
종
Human (6)Mouse (1)Rat (2)Cynomolgus (2)Rabbit (1)
태그
His Tag (7)His Tag & Avi Tag (3)Fc Tag (1)- (1)
마커
Unconjugated (8)Biotin-labeled (3)- (1)

제품 번호	종	발현 시스템	제품 설명
HOT CO5-H52Ha	Human	HEK293	Human Complement C5 Protein, His Tag, low endotoxin (MALS verified)
HOT CO5-H82E9	Human	HEK293	Biotinylated Human Complement C5 Protein, His,Avitag™ (MALS verified)
HOT CO5-M52H4	Mouse	HEK293	Mouse Complement C5 Protein, His Tag
HOT CO5-R52H5	Rat	HEK293	Rat Complement C5 Protein, His Tag
CEA-B241	Human	-	Human Complement C5 ELISA Kit
CO5-H5253	Human	HEK293	Human Complement C5 Protein, Fc Tag
CO5-H52H7	Human	HEK293	Human Complement C5 (w917s) Protein, His Tag (MALS verified)
CO5-H52Hx	Human	HEK293	Human Complement C5 (R885H) Protein, His Tag
CO5-C52Hx	Cynomolgus	HEK293	Cynomolgus Complement C5 Protein, His Tag (MALS verified)
CO5-C82E3	Cynomolgus	HEK293	Biotinylated Cynomolgus Complement C5 Protein, His,Avitag™ (MALS verified)

총 수량12

Complement C5분자 배경

Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. C5 precursor is first processed by the removal of 4 basic residues, forming two chains, beta and alpha, linked by a disulfide bond. C5 convertase activates C5 by cleaving the alpha chain, releasing C5a anaphylatoxin and generating C5b (beta chain + alpha' chain). Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. The C5a anaphylatoxin interacts with C5AR1 and tick complement inhibitor. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.

Complement C5분자 별명

Complement C5,C5,CPAMD4

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Eculizumab biosimilar (CinnaGen)		Phase 3 Clinical	Cinnagen	Hemoglobinuria, Paroxysmal	상세
Eculizumab biosimilar (IBC GENERIUM)		Phase 3 Clinical	Ibc Generium	Atypical Hemolytic Uremic Syndrome; Hemoglobinuria, Paroxysmal	상세
Eculizumab biosimilar (Biocad)	BCD-148	Phase 3 Clinical	BIOCAD JSC	Hemoglobinuria, Paroxysmal	상세
Cemdisiran	ALN-CC5; AD-62643; ALN-62643; L96	Phase 3 Clinical	Alnylam Pharmaceuticals Inc	Atypical Hemolytic Uremic Syndrome; Geographic Atrophy; Glomerulonephritis, IGA; Hemoglobinuria, Paroxysmal; Macular Degeneration; Myasthenia Gravis; Myositis; Myositis, Inclusion Body	상세
Tesidolumab	NOV-4; LFG-316	Phase 2 Clinical	Morphosys Ag, Novartis Pharma Ag	Geographic Atrophy; Hemoglobinuria, Paroxysmal; Macular Degeneration; Panuveitis; Rejection of renal transplantation; Uveitis, Intermediate; Uveitis, Posterior; Wet Macular Degeneration	상세
IM-101	IM-101	Phase 2 Clinical	ImmunAbs Inc	Autoimmune Diseases; Myasthenia Gravis	상세
ABBV-6628	ABBV-6628	Phase 2 Clinical	Abbvie Inc	Geographic Atrophy; Macular Degeneration	상세
OCUL-101	OCUL101	Phase 2 Clinical	Shenzhen Oukejian Biomedical Technology Co Ltd	Diabetic macular oedema; Geographic Atrophy; Macular Degeneration; Retinal Neovascularization	상세
KRIYA-825	KRIYA-825; VV-14295	Phase 2 Clinical	Kriya Therapeutics Inc	Geographic Atrophy	상세
LP-005	LP-005; RX-001	Phase 2 Clinical	Longbio Pharma (Suzhou) Co Ltd	Amyotrophic Lateral Sclerosis; C3 glomerulopathy; Carcinoma, Non-Small-Cell Lung; Complement-Mediated Diseases; Glomerulonephritis, IGA; Glomerulonephritis, Membranoproliferative; Hemoglobinuria, Paroxysmal; Kidney Diseases; Lupus Nephritis; Myasthenia Gravis; Periodontal Diseases; Peripheral Nervous System Diseases; Thrombotic Microangiopathies	상세
Vensobafusp alfa	P014; KP-104	Phase 2 Clinical	Kira Pharmaceuticals LLC	Glomerulonephritis; Glomerulonephritis, IGA; Hemoglobinuria, Paroxysmal; Kidney Diseases; Lupus Erythematosus, Systemic; Thrombotic Microangiopathies	상세
Omoprubart	CAN-106	Phase 2 Clinical	Beihai Kangcheng (Beijing) Pharmaceutical Technology Co Ltd	Genetic Diseases, Inborn; Hemoglobinuria, Paroxysmal	상세
ALXN-5500	ALXN-5500	Phase 1 Clinical	Alexion Pharmaceuticals Inc	Hemoglobinuria, Paroxysmal	상세
RLYB-116	RLYB-116	Phase 1 Clinical	Affibody Ab, Swedish Orphan Biovitrum (Sobi)	Autoimmune Diseases; Hematologic Diseases; Immune System Diseases; Inflammation	상세
SYH-2061	SYH2061; SYH-2061	Phase 1 Clinical	CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co Ltd	Complement-Mediated Diseases; Glomerulonephritis, IGA; Nephrosis	상세
NM3086	NM3086; NM-3086	Phase 1 Clinical	NovelMed Therapeutics Inc	Hemoglobinuria, Paroxysmal	상세
Eculizumab biosimilar (Turgut Ardika)	TUR03; TUR-03	Phase 1 Clinical	Turgut Ardika Pty Ltd		상세
EA-5	EA-5; EA5	Phase 1 Clinical	Shandong Lanyi Pharmaceutical Technology Co Ltd	Antiphospholipid Syndrome; Hemoglobinuria, Paroxysmal; Kidney Diseases; Myasthenia Gravis; Thrombotic Microangiopathies	상세
RBD-7007	RBD-7007	Phase 1 Clinical	Suzhou Ribo Life Science Co Ltd	Glomerulonephritis, IGA	상세
eculizumab biosimilar(Isu Abxis)	ISU-305	Phase 1 Clinical	Isu Abxis Co Ltd	Atypical Hemolytic Uremic Syndrome; Hemoglobinuria, Paroxysmal	상세

시판 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	가장 빠른 브랜드 이름	가장 빠른 승인 국가	가장 빠른 적응증	가장 빠른 승인 회사	가장 빠른 승인 날짜	적응증	임상 시험
Avacincaptad pegol sodium	ARC-1905; ARC-187	Approved	Archemix Corp	Zimura, Izervay	United States	Macular Degeneration; Geographic Atrophy	Iveric Bio Inc, Astellas Pharma Inc	2023-08-04	Geographic Atrophy; Macular Degeneration; Polypoidal choroidal vasculopathy	상세
Zilucoplan Sodium	RA-101495-SC; RA-101495; ZLP-AI	Approved	Ra Pharmaceuticals Inc, Ucb Sa	ZILBRYSQ, Zilbrysq, 卓倍可	Japan	Myasthenia Gravis	Ucb Japan Co Ltd	2023-09-25	Amyotrophic Lateral Sclerosis; Coronavirus Disease 2019 (COVID-19); Hemoglobinuria, Paroxysmal; Muscular Diseases; Myasthenia Gravis	상세
Crovalimab	RO-7112689/F01; SKY-59; RO711269; RO-711269; RG-6107; CH-7092230; RO-7092230; RO-7112689	Approved	Chugai Pharmaceutical Co Ltd, F. Hoffmann-La Roche Ltd	派圣凯, Piasky	Mainland China	Hemoglobinuria, Paroxysmal	Roche Pharma (Schweiz) Ag, Roche (China) Holding Ltd, Genentech Inc	2024-02-06	Anemia, Sickle Cell; Antiphospholipid Syndrome; Atypical Hemolytic Uremic Syndrome; Guillain-Barre Syndrome; Hemoglobinuria, Paroxysmal	상세
Ravulizumab	ALXN-1810; ALXN-1210	Approved	Alexion Pharmaceuticals Inc, Xencor Inc	Ultomiris, 伟立瑞	United States	Hemoglobinuria, Paroxysmal	Alexion Pharmaceuticals Inc	2018-12-21	Acute Kidney Injury; Acute Lung Injury; Amyotrophic Lateral Sclerosis; Atypical Hemolytic Uremic Syndrome; Coronavirus Disease 2019 (COVID-19); Delayed Graft Function; Dermatomyositis; Glomerulonephritis, IGA; Heart Diseases; Hemoglobinuria, Paroxysmal; Immunoglobulin A Vasculitis Associated Nephritis; Kidney Diseases; Kidney Failure, Chronic; Lupus Nephritis; Myasthenia Gravis; Neuromyelitis Optica; Pneumonia, Viral; Purpura, Schoenlein-Henoch; Rejection of renal transplantation; Renal Insufficiency, Chronic; Respiratory Distress Syndrome, Adult; Thrombotic Microangiopathies	상세
Eculizumab	LEX-98; h-5G1.1; 5G1-1; HAL-1	Approved	Alexion Pharmaceuticals Inc	Soliris, 舒立瑞	United States	Hemoglobinuria, Paroxysmal	Alexion Pharmaceuticals Inc	2007-03-16	Anemia, Hemolytic, Autoimmune; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Antiphospholipid Syndrome; Asthma; Atypical Hemolytic Uremic Syndrome; Delayed Graft Function; Diabetes Mellitus; End Stage Liver Disease; Glomerulonephritis, Membranoproliferative; Guillain-Barre Syndrome; HELLP Syndrome; Hemoglobinuria, Paroxysmal; Infant, Newborn, Diseases; Kidney Failure, Chronic; Macular Degeneration; Myasthenia Gravis; Nasopharyngeal Carcinoma; Neuromyelitis Optica; Parturition; Pre-Eclampsia; Rejection of renal transplantation; Rejection of organ transplantation; Thrombocytopenia; Urea Cycle Disorders, Inborn; Vagus Nerve Diseases	상세
Pozelimab	REGN-3918	Approved	Regeneron Pharmaceuticals Inc	VEOPOZ	United States	Protein-Losing Enteropathies	Regeneron Pharmaceuticals Inc	2023-08-18	Geographic Atrophy; Hemoglobinuria, Paroxysmal; Myasthenia Gravis; Protein-Losing Enteropathies	상세
Eculizumab biosimilar (Amgen)	ABP-959	Approved	Amgen Inc	BKEMV	United States	Hemoglobinuria, Paroxysmal; Atypical Hemolytic Uremic Syndrome	Amgen Inc	2024-05-28	Atypical Hemolytic Uremic Syndrome; Hemoglobinuria, Paroxysmal	상세
Eculizumab biosimilar (Samsung Bioepis)	SB-12; AM004; AMT-904; SB12	Approved	Samsung Bioepis Co Ltd	Epysqli, EPYSQLI	EU	Atypical Hemolytic Uremic Syndrome; Hemoglobinuria, Paroxysmal	Samsung Bioepis Nl Bv	2023-05-26	Atypical Hemolytic Uremic Syndrome; Hemoglobinuria, Paroxysmal	상세

제품 리뷰

1***32022-08-10
0사람들이 좋아합니다
Cynomolgus Complement C5 Protein, His Tag (MALS verified)
I tried to express this product myself and it didn’t work, so I purchased ACRO’s products for antibody screening. The binding activity is very good and method establishment is also going very smoothly. There is also complete technical support available to help us solve any problems that arise during our experiments.