언어 선택

B7-H5

B7-H5 분자 정보

영어 이름	V-domain Ig suppressor of T-cell activation	시판 약물 수	0
임상 약물 수	8	표적 별명	Dies1，VSIR，V-Set Domain-Containing Immunoregulatory Receptor，DD1alpha，B7-H5，PD-1H，B7H5，GI24，Stress-induced secreted protein-1，PP2135，SISP1，UNQ730/PRO1412，V-type immunoglobulin domain-containing suppressor of T-cell activation，V-Set Immunoregulatory Receptor，V-Domain Ig Suppressor Of T Cell Activation，PDCD1 Homolog，C10orf54，Sisp-1，VISTA，Chromosome 10 Open Reading Frame 54，Stress Induced Secreted Protein 1，Platelet Receptor Gi24，Death Domain1alpha
최고 연구 개발 단계	Phase 3 Clinical

영어 이름	V-domain Ig suppressor of T-cell activation
표적 별명	Dies1，VSIR，V-Set Domain-Containing Immunoregulatory Receptor，DD1alpha，B7-H5，PD-1H，B7H5，GI24，Stress-induced secreted protein-1，PP2135，SISP1，UNQ730/PRO1412，V-type immunoglobulin domain-containing suppressor of T-cell activation，V-Set Immunoregulatory Receptor，V-Domain Ig Suppressor Of T Cell Activation，PDCD1 Homolog，C10orf54，Sisp-1，VISTA，Chromosome 10 Open Reading Frame 54，Stress Induced Secreted Protein 1，Platelet Receptor Gi24，Death Domain1alpha
시판 약물 수	0
임상 약물 수	8
최고 연구 개발 단계	Phase 3 Clinical

B7-H5 제품 목록

속성
Protein (7)
제품 라이브러리
온라인 (7)
종
Human (5)Rhesus macaque (1)Mouse (1)
태그
His Tag (3)Fc Tag (1)His Tag & Avi Tag (1)Fc Tag & Avi Tag (1)Mouse IgG Fc Tag (1)
마커
Unconjugated (5)Biotin-labeled (2)

제품 번호	종	발현 시스템	제품 설명
HOT B75-H5258	Human	HEK293	Human B7-H5 / Gi24 / VISTA Protein, Mouse IgG2a Fc Tag, low endotoxin
HOT B75-H5259	Human	HEK293	Human B7-H5 / Gi24 / VISTA Protein, Fc Tag
HOT B75-H52H0	Human	HEK293	Human B7-H5 / Gi24 / VISTA Protein, His Tag (MALS verified)
HOT B75-H82E1	Human	HEK293	Biotinylated Human B7-H5 / Gi24 / VISTA Protein, Avitag™,His Tag
HOT B75-H82F3	Human	HEK293	Biotinylated Human B7-H5 / Gi24 / VISTA Protein, Fc,Avitag™
B75-M52H7	Mouse	HEK293	Mouse B7-H5 / Gi24 / VISTA Protein, His Tag
B75-C5220	Rhesus macaque	HEK293	Rhesus macaque B7-H5 / Gi24 / VISTA Protein, His Tag

총 수량7

B7-H5분자 배경

Platelet receptor Gi24, also known as B7-H5 and stress-induced secreted protein-1 (Sisp-1), is a protein that in humans is encoded by the C10orf54 gene, which contains 1 Ig-like (immunoglobulin-like) domain. As for C10orf54 gene, C10orf54 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state on ESCs. Human C10orf54 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30 kDa extracellular fragment plus a 25-30 kDa membrane-bound fragment.

B7-H5분자 별명

B7-H5,SISP1,Gi24,VISTA

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
CA-170	CA-170; AUPM-170	Phase 3 Clinical	Aurigene	Carcinoma, Non-Small-Cell Lung; Neoplasms; Solid tumours	상세
Solnerstotug	SNS-101; SNS-VISTA	Phase 2 Clinical	Sensei Biotherapeutics Inc	Breast Neoplasms; Carcinoma, Merkel Cell; Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; Esophageal Neoplasms; Head and Neck Neoplasms; Kidney Neoplasms; Melanoma; Neoplasm Metastasis; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Sarcoma; Solid tumours; Stomach Neoplasms; Thyroid Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms	상세
Trovostobart	KVA-12123; KVA-12.1	Phase 2 Clinical	GigaGen Inc	Breast Neoplasms; Carcinoma; Colorectal Neoplasms; Esophageal Neoplasms; Head and Neck Neoplasms; Kidney Neoplasms; Lung Neoplasms; Melanoma; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Sarcoma; Solid tumours; Stomach Neoplasms; Thyroid Neoplasms; Uterine Neoplasms	상세
Onvatilimab	CI-8993; JNJ-61610588	Phase 1 Clinical	Immunext Inc, Johnson & Johnson Innovative Medicine	Neoplasms; Solid tumours	상세
HMBD-002	HMBD-002	Phase 1 Clinical	Hummingbird Bioscience	Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis; Neoplasms; Solid tumours; Triple Negative Breast Neoplasms	상세
PMC-309	PMC-309	Phase 1 Clinical	Pharmabcine	Neoplasms; Solid tumours	상세
TBS-2025	TBS-2025	Phase 1 Clinical	Kintara Therapeutics Inc	Leukemia, Myeloid, Acute	상세
LFD-200	LFD-200	Phase 1 Clinical	Lifordi Immunotherapeutics Inc	Arthritis, Rheumatoid	상세