언어 선택

STAT3

STAT3 분자 정보

영어 이름	Signal transducer and activator of transcription 3	시판 약물 수	4
임상 약물 수	21	표적 별명	Acute-phase response factor，APRF，STAT3，Signal Transducer And Activator Of Transcription 3 (Acute-Phase Response Factor)，Signal transducer and activator of transcription 3，DNA-Binding Protein APRF，ADMIO1，ADMIO，HIES，STAT3 Transcription Factor
최고 연구 개발 단계	Approved

영어 이름	Signal transducer and activator of transcription 3
표적 별명	Acute-phase response factor，APRF，STAT3，Signal Transducer And Activator Of Transcription 3 (Acute-Phase Response Factor)，Signal transducer and activator of transcription 3，DNA-Binding Protein APRF，ADMIO1，ADMIO，HIES，STAT3 Transcription Factor
시판 약물 수	4
임상 약물 수	21
최고 연구 개발 단계	Approved

STAT3 제품 목록

속성
Cell (1)Protein (1)
제품 라이브러리
온라인 (2)
종
Human (2)
태그
- (1)His Tag (1)
마커
- (1)Unconjugated (1)

제품 번호	종	발현 시스템	제품 설명	단백질 구조	순도	특성
CHEK-ATF047	Human	HEK293	STAT3 (Luc) HEK293 Reporter Cell
ST3-H5149	Human	E. coli	Human STAT3 Protein, His Tag, low endotoxin (MALS & SPR verified)

총 수량2

STAT3분자 배경

Signal transducer and activator of transcription 3 (STAT3) regulates the expression of genes important for essential cellular processes including survival, proliferation, self-renewal, angiogenesis, and immune response. As an early tumor diagnostic marker, it is considered that constitutive STAT3 activation is a sufficient factor to cause malignant transformation and tumor development in model systems. The classical IL-6/STAT3 signaling pathway in cancer cells. IL-6 binds to the membrane-bound IL-6 receptor α (IL-6R) and IL-6 receptor β (also known as gp130). The IL-6/IL-6R/gp130 complex activate the phosphorylation of JAKs, followed by STAT3 phosphorylation and activation. Then, phosphorylated STAT3 forms a homodimer and translocates into the nucleus to bind to the promotor region of target genes and activates target gene transcription.

STAT3분자 별명

STAT3, signal transducer and activator of transcription 3

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Napabucasin	DP1; DP2A; BB-608; GB-201; BBI-608; BBI-608-DP1; BBI-608-DP2A; Z1HHM49K7O (UNII code)	Phase 3 Clinical	1globe Biomedical Co Ltd, Boston Biomedical Inc, Pharmaceutics International Inc	Adenocarcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Colorectal Neoplasms; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Gastrointestinal Neoplasms; Glioblastoma; Hematologic Neoplasms; Mesothelioma; Neoplasms; Pancreatic Neoplasms; Solid tumours; Stomach Neoplasms	상세
Isoquercetin	IQC-950AN; ISQ950AN	Phase 3 Clinical	Quercegen Pharmaceuticals	Anemia, Sickle Cell; beta-Thalassemia; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Coronavirus Disease 2019 (COVID-19); Diabetic Nephropathies; Kidney Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Renal Insufficiency, Chronic; Venous Thromboembolism	상세
Dimethylaminomicheliolide Fumarate	ACT-001	Phase 3 Clinical	Tianjin Accendatech Technology Co Ltd	Brain metastases; Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Central Nervous System Neoplasms; Glioblastoma; Glioma; Melanoma; Neuromyelitis Optica; Optic Neuritis; Small Cell Lung Carcinoma; Solid tumours	상세
Nanocurcumin (Tehran University of Medical Sciences)		Phase 2 Clinical	Tehran University Of Medical Sciences	Neoplasms; Periapical Diseases	상세
Danvatirsen	AZD-9150; STAT-3Rx; ISIS-345794; ISIS-481464; ISIS-STAT3Rx; IONIS-STAT3Rx; ISIS-STAT3-2.5Rx; IONIS-STAT3-2.5Rx	Phase 2 Clinical	Ionis Pharmaceuticals Inc	Ascites; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Gastrointestinal Neoplasms; Lung Neoplasms; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Mismatch Repair Deficient Cancer; Ovarian Neoplasms; Pancreatic Neoplasms; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms	상세
M-1001	M-1001; MEDICA-M1001	Phase 2 Clinical	Syndromex	Dyslipidemias	상세
Ivarmacitinib sulfate Base gel(Jiangsu Hengrui Medicine)	SHR0302 base	Phase 2 Clinical	Jiangsu Hengrui Medicine Co Ltd	Vitiligo	상세
NT-219	NT-219; NT219	Phase 2 Clinical	TyrNovo Ltd	Colorectal Neoplasms; Head and Neck Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck	상세
C-188-9	C188-9; C-188-9; TTI-101	Phase 2 Clinical	Baylor College Of Medicine	Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Idiopathic Pulmonary Fibrosis; Melanoma; Neoplasms; Pancreatic Neoplasms; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms	상세
WP-1066	WP-1066	Phase 2 Clinical	Moleculin Biotech Inc	Brain metastases; Brain Neoplasms; Diffuse Intrinsic Pontine Glioma; Glioblastoma; Glioma; Medulloblastoma; Melanoma	상세
OPB-111077	OPB-111077; OPC-317	Phase 1 Clinical	Otsuka Pharmaceutical Co Ltd	Carcinoma, Hepatocellular; Leukemia, Myeloid, Acute; Lymphoma, Large B-Cell, Diffuse; Nasopharyngeal Carcinoma; Neoplasms; Solid tumours	상세
YY-201	YY-201; YY201	Phase 1 Clinical	Shanghai Yuyao Biotechnology Co Ltd	Carcinoma, Non-Small-Cell Lung; Hematologic Neoplasms; Leukemia, Myeloid, Acute; Lymphoma, Extranodal NK-T-Cell; Pancreatic Neoplasms; Solid tumours	상세
GLG-302	GLG-302; GLG-805; S31-201; NSC-74859	Phase 1 Clinical	H Lee Moffitt Cancer Center & Research Institute	Breast Neoplasms	상세
Amcasertib/Napabucasin		Phase 1 Clinical	Boston Biomedical Inc	Neoplasms	상세
JW-2286	ST-2286; JW2286; JW-2286	Phase 1 Clinical	C&C Research Laboratories	Breast Neoplasms; Colorectal Neoplasms; Solid tumours; Stomach Neoplasms	상세
Lirodegimod	KT-333; I-003	Phase 1 Clinical	Kymera Therapeutics Inc	Leukemia, Lymphoid; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral; Solid tumours	상세
NN-4002	NN4002; NN-4002	Phase 1 Clinical	Novo Nordisk A/S	Lymphoma, Non-Hodgkin; Solid tumours	상세
VVD-130850	VVD-130850; BAY-3630914; VVD-850	Phase 1 Clinical	Vividion Therapeutics Inc	Hematologic Neoplasms; Solid tumours	상세
DCR-STAT3	DCR-STAT3	Phase 1 Clinical	Dicerna Pharmaceuticals Inc	Neoplasms; Solid tumours	상세
OPB-171775	OPB-171775	Phase 1 Clinical	Otsuka Pharmaceutical Co Ltd	Metabolic Dysfunction-Associated Steatotic Liver Disease	상세
STAT3 decoys (University of Pittsburgh/University of Pittsburgh-Office of Technology Management)		Clinical	University Of Pittsburgh	Neoplasms	상세

시판 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	가장 빠른 브랜드 이름	가장 빠른 승인 국가	가장 빠른 적응증	가장 빠른 승인 회사	가장 빠른 승인 날짜	적응증	임상 시험
Golotimod	SCV-07	Approved	Verta		Russian Federation	Mucositis; Hepatitis C	null	2009-01-01	Head and Neck Neoplasms; Hepatitis C; Mucositis; Stomatitis	상세
Ivarmacitinib sulfate	SHR-0302; ARQ-252; ARQ-255	Approved	Jiangsu Hengrui Medicine Co Ltd	艾速达	Mainland China	Spondylitis, Ankylosing	Jiangsu Hengrui Medicine Co Ltd	2025-03-18	Alopecia Areata; Arthritis, Psoriatic; Arthritis, Rheumatoid; Autoimmune Diseases; Colitis, Ulcerative; Crohn Disease; Dermatitis, Atopic; Eczema; Graft vs Host Disease; Hepatic Insufficiency; Lupus Erythematosus, Systemic; Lymphoma, T-Cell, Peripheral; Metastatic breast cancer; Non-radiographic axial spondyloarthritis; Sedation; Solid tumours; Spondylarthritis; Spondylitis, Ankylosing; Triple Negative Breast Neoplasms; Vitiligo	상세
Nifuroxazide		Approved		Ambatrol					Colitis; Diarrhea	상세
Caffeic Acid	CABE	Approved	Moleculin Llc, The University Of Texas MD Anderson Cancer Center						Hemorrhage; Leukopenia; Thrombocytopenia	상세