언어 선택

RAGE

RAGE 분자 정보

영어 이름	Advanced glycosylation end product-specific receptor	시판 약물 수	0
임상 약물 수	3	표적 별명	Receptor for advanced glycosylation end products，AGER，Advanced Glycosylation End-Product Specific Receptor，RAGE，Receptor For Advanced Glycation End-Products Variant 20，Receptor For Advanced Glycation End-Products，RAGE Isoform NtRAGE-Delta，RAGE Isoform SRAGE-Delta，SCARJ1，Receptor for Advanced Glycation End Products，Advanced glycosylation end product-specific receptor
최고 연구 개발 단계	Phase 3 Clinical

영어 이름	Advanced glycosylation end product-specific receptor
표적 별명	Receptor for advanced glycosylation end products，AGER，Advanced Glycosylation End-Product Specific Receptor，RAGE，Receptor For Advanced Glycation End-Products Variant 20，Receptor For Advanced Glycation End-Products，RAGE Isoform NtRAGE-Delta，RAGE Isoform SRAGE-Delta，SCARJ1，Receptor for Advanced Glycation End Products，Advanced glycosylation end product-specific receptor
시판 약물 수	0
임상 약물 수	3
최고 연구 개발 단계	Phase 3 Clinical

RAGE 제품 목록

속성
Cell (1)
제품 라이브러리
온라인 (1)
종
Human (1)
태그
- (1)
마커
- (1)

제품 번호	종	발현 시스템	제품 설명	단백질 구조	순도	특성
CHEK-ATP156	Human	HEK293	HEK293/Human RAGE Stable Cell Line

총 수량1

RAGE분자 배경

Advanced glycosylation end product-specific receptor (AGER) is also known as RAGE, and is a single-pass type I membrane protein which contains two Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. AGER is highly expressed in endothelial cells. AGER mediates interactions of advanced glycosylation end products (AGE), and also accumulates in vascular tissue in aging and at an accelerated rate in diabetes, as well as acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGER / RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes.

RAGE분자 별명

AGER,RAGE

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
Azeliragon	TTP-488; PF-4494700; PF-04494700	Phase 3 Clinical	Vtv Therapeutics	Alzheimer Disease; Brain metastases; Breast Neoplasms; Coronavirus Disease 2019 (COVID-19); Diabetic Nephropathies; Glioblastoma; Glioma; Neoplasm Metastasis; Neoplasms; Pancreatic Neoplasms	상세
TRC-4186	TX-41XX; TRC-4186	Phase 2 Clinical	Torrent Pharmaceuticals Ltd	Diabetes Complications; Heart Failure	상세
ARO-RAGE		Phase 2 Clinical	Arrowhead Pharmaceuticals Inc	Asthma	상세