언어 선택

MCAM

MCAM 분자 정보

영어 이름	Melanoma cell adhesion molecule	시판 약물 수	0
임상 약물 수	2	표적 별명	METCAM，CD146，Melanoma cell adhesion molecule，MCAM，Cell surface glycoprotein MUC18，S-Endo 1 Endothelial-Associated Antigen，Melanoma-Associated Antigen MUC18，Melanoma-Associated Antigen A32，Gicerin，MUC18，CD146 Antigen，Cell surface glycoprotein P1H12，Melanoma Adhesion Molecule，MelCAM，HEMCAM
최고 연구 개발 단계	Phase 2 Clinical

영어 이름	Melanoma cell adhesion molecule
표적 별명	METCAM，CD146，Melanoma cell adhesion molecule，MCAM，Cell surface glycoprotein MUC18，S-Endo 1 Endothelial-Associated Antigen，Melanoma-Associated Antigen MUC18，Melanoma-Associated Antigen A32，Gicerin，MUC18，CD146 Antigen，Cell surface glycoprotein P1H12，Melanoma Adhesion Molecule，MelCAM，HEMCAM
시판 약물 수	0
임상 약물 수	2
최고 연구 개발 단계	Phase 2 Clinical

MCAM 제품 목록

속성
Protein (3)Cell (1)
제품 라이브러리
온라인 (4)
종
Human (3)Mouse (1)
태그
His Tag (2)- (1)His Tag & Avi Tag (1)
마커
Unconjugated (2)- (1)Biotin-labeled (1)

제품 번호	종	발현 시스템	제품 설명
CD6-H5229	Human	HEK293	Human MCAM / CD146 Protein, His Tag
CHEK-ATP195	Human	HEK293	HEK293/Human MCAM Stable Cell Line
MCM-H82E3	Human	HEK293	Biotinylated Human MCAM / CD146 Protein, His,Avitag™ (MALS verified)
MCM-M52H3	Mouse	HEK293	Mouse MCAM / CD146 Protein, His Tag

총 수량4

MCAM분자 배경

CD146, also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. As a member of the Immunoglobulin superfamily, It is expressed on chicken embryonic spleen and thymus, activated human T cells, endothelial progenitors such as angioblasts and mesenchymal stem cells, and strongly expressed on blood vessel endothelium and smooth muscle. CD146 has been demonstrated to appear on a small subset of T and B lymphocytes in the peripheral blood of healthy individuals. The CD146+ T cells display an immunophenotype consistent with effector memory cells and have a distinct gene profile from the CD146- T cells. As a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor,CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis or immune recognition.

MCAM분자 별명

MCAM,CD146,MUC18

임상 약물 정보

영어 이름	연구 코드	연구 개발 단계	회사	적응증	임상 시험
CD146 targeting CAR-T cell therapy (Essen Biotech)		Phase 2 Clinical	Essen Biotech	Carcinoma, Ovarian Epithelial; Osteosarcoma; Ovarian Neoplasms; Sarcoma; Sarcoma, Ewing; Sarcoma, Kaposi; Sarcoma, Synovial	상세
AMT-253(Multitude)	AMT-253; AMT-253 ADC	Phase 2 Clinical	Multitude Therapeutics Inc	Melanoma; Solid tumours	상세